Upstream Bioprocessing Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The report covers Upstream Bioprocessing Challenges and the market is segmented by Product (Cell Culture Products, Bioreactors/Fermenters, Filters, Bioreactors Accessories, and Other Products), Usage Type (Single-Use and Multi-Use), Mode (In-house and Outsourced), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market provides the value (in USD million) for the above-mentioned segments.

Upstream Bioprocessing Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

Upstream Bioprocessing Market Size

Upstream Bioprocessing Market Summary
Study Period 2019 - 2030
Base Year For Estimation 2024
Forecast Data Period 2025 - 2030
CAGR 5.50 %
Fastest Growing Market Asia Pacific
Largest Market North America
Market Concentration Low

Major Players

Upstream Bioprocessing Market Major Players

*Disclaimer: Major Players sorted in no particular order

Compare market size and growth of Upstream Bioprocessing Market with other markets in Healthcare Industry

Biotechnology

Pharmaceuticals

Healthcare IT

Medical Devices

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Device Drug Combination

Upstream Bioprocessing Market Analysis

The Upstream Bioprocessing Market is expected to register a CAGR of 5.5% during the forecast period.

  • The COVID-19 pandemic significantly impacted the upstream bioprocessing market, as drug manufacturers focused on developing vaccines and medications for COVID-19 diagnosis and treatment. The need for efficient development of new upstream bioprocesses became more crucial during the pandemic. This resulted in a surge in upstream bioprocessing rates, which contributed to market growth. However, as COVID-19 cases decline, the market is stabilizing, returning to pre-pandemic levels.
  • Over the forecast period, the rising adoption of single-use upstream bioprocessing, commercial success and demand for biotherapeutics, and increasing research activities are expected to drive the market's growth. Advanced upstream bioprocessing technologies are essential in developing and scaling up manufacturing operations and analytical testing capabilities. These processes are crucial in the research activities to develop biosimilars, therapeutic peptides, and monoclonal antibodies. Upstream bioprocessing's contamination-free, safe, and efficient production further propels the market. With solid investments in R&D activities and a pipeline of therapeutics under development, upstream bioprocessing is expected to grow significantly.
  • The increasing investment in research and development by phramceutical industry across the world is also expected to contribute to the growth of the market. For instance, according European Federation of Pharmaceutical Association the research and development expenditure incureeed in Europe by Pharmaceutical industry was EUR 42.53 billion (USD 44.72 billion) in 2022 and This is expected to increase to EUR 44.50 billion (USD 46.79 billion) in 2023. Such increase in R&D also creates need for the upsteam bioprocessing products and hence expected to propel the growth of the market.
  • The launch of technologically advanced and innovative products also drives the market's growth. For example, Thermo Fisher Scientific launched its new Gibco Human Plasma-like Medium (HPLM) to provide researchers with a realistic view of cell growth within the human body. Nucleus Biologics launched Krakatoa, which is a creative, one of the first-to-market media makers that help researchers manufacture cell culture media at the point of use.
  • Although the market has promising growth potential, operational challenges regarding upstream bioprocessing are expected to restrain the market's growth over the forecast period.

Upstream Bioprocessing Industry Overview

The upstream bioprocessing market is highly competitive and fragmented, with numerous companies operating globally and regionally. The competitive landscape includes both international and local companies that hold significant market shares. Key players in this market include Thermo Fisher Scientific Inc., Danaher Corporation (Cytvia), Corning, Inc., Merck KGaA, Eppendorf AG, Sartorius AG, Boehringer Ingelheim GmbH, Applikon Biotechnology, and CellGenix GmbH. These companies are well known for their innovative products, strong distribution networks, and comprehensive service offerings, which help them maintain a dominant position in the market.

Upstream Bioprocessing Market Leaders

  1. Thermo Fisher Scientific Inc.

  2. Corning, Inc

  3. Merck KGaA

  4. Sartorius AG

  5. Danaher Corporation (Cytvia)

  6. *Disclaimer: Major Players sorted in no particular order
Upstream Bioprocessing Market Concentration
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Upstream Bioprocessing Market News

  • April 2022: High Purity New England (HPNE) announced the launch of a new manufacturing facility, which represents a USD 10 million investment. The facility serves as HPNE's Specialty Manufacturing and Distribution Center and significantly increases the company's manufacturing capacity for single-use solutions.
  • February 2022: Thermo Fisher Scientific invested USD 40 million to expand its single-use technology manufacturing facility in Millersburg, Pennsylvania. This expansion is part of the company's USD 650 million multi-year investment plan to enhance its capacity to provide flexible, scalable, and reliable bioprocessing production solutions.

Upstream Bioprocessing Market Report - Table of Contents

1. INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2. RESEARCH METHODOLOGY

3. EXECUTIVE SUMMARY

4. MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising Adoption of Single-use Upstream Bioprocessing
    • 4.2.2 Commercial Success and Rising Demand for Biotherapeutics
  • 4.3 Market Restraints
    • 4.3.1 Operational Challenges Pertaining to Upstream Bioprocessing
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5. MARKET SEGMENTATION (Market Size by Value - USD)

  • 5.1 By Product
    • 5.1.1 Cell Culture Products
    • 5.1.2 Bioreactors/Fermenters
    • 5.1.3 Filters
    • 5.1.4 Bioreactors Accessories
    • 5.1.5 Other Products
  • 5.2 By Usage Type
    • 5.2.1 Single-Use
    • 5.2.2 Multi-Use
  • 5.3 By Mode
    • 5.3.1 In-house
    • 5.3.2 Outsourced
  • 5.4 Geography
    • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
    • 5.4.2 Europe
    • 5.4.2.1 Germany
    • 5.4.2.2 United Kingdom
    • 5.4.2.3 France
    • 5.4.2.4 Italy
    • 5.4.2.5 Spain
    • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
    • 5.4.3.1 China
    • 5.4.3.2 Japan
    • 5.4.3.3 India
    • 5.4.3.4 Australia
    • 5.4.3.5 South Korea
    • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East and Africa
    • 5.4.4.1 GCC
    • 5.4.4.2 South Africa
    • 5.4.4.3 Rest of Middle East and Africa
    • 5.4.5 South America
    • 5.4.5.1 Brazil
    • 5.4.5.2 Argentina
    • 5.4.5.3 Rest of South America

6. COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Thermo Fisher Scientific Inc.
    • 6.1.2 Danaher Corporation (Cytvia)
    • 6.1.3 Corning, Inc.
    • 6.1.4 Merck KGaA
    • 6.1.5 Eppendorf AG
    • 6.1.6 Sartorius AG
    • 6.1.7 Boehringer Ingelheim GmbH
    • 6.1.8 Entegris
    • 6.1.9 Applikon Biotechnology
    • 6.1.10 CellGenix GmbH
    • 6.1.11 Getinge AB
    • 6.1.12 Avantor
    • 6.1.13 Cesco Bioengneering Co., Ltd.
    • 6.1.14 Cellexus
  • *List Not Exhaustive

7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments
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Upstream Bioprocessing Industry Segmentation

As per the scope, upstream bioprocessing involves using living cells to obtain desired products. This process starts from early cell separation and cultivation to cell culture expansion to harvest the final product.

The upstream bioprocessing market is segmented by product (cell culture products, bioreactors/fermenters, filters, bioreactors accessories, and other products), usage type (single-use and multi-use), mode (in-house and outsourced), and geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report also covers the estimated market sizes and trends for 17 countries across major regions globally.

The report offers the value (in USD) for the above segments.

By Product Cell Culture Products
Bioreactors/Fermenters
Filters
Bioreactors Accessories
Other Products
By Usage Type Single-Use
Multi-Use
By Mode In-house
Outsourced
Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
South America Brazil
Argentina
Rest of South America
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Upstream Bioprocessing Market Research FAQs

What is the current Upstream Bioprocessing Market size?

The Upstream Bioprocessing Market is projected to register a CAGR of 5.5% during the forecast period (2025-2030)

Who are the key players in Upstream Bioprocessing Market?

Thermo Fisher Scientific Inc., Corning, Inc, Merck KGaA, Sartorius AG and Danaher Corporation (Cytvia) are the major companies operating in the Upstream Bioprocessing Market.

Which is the fastest growing region in Upstream Bioprocessing Market?

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Which region has the biggest share in Upstream Bioprocessing Market?

In 2025, the North America accounts for the largest market share in Upstream Bioprocessing Market.

What years does this Upstream Bioprocessing Market cover?

The report covers the Upstream Bioprocessing Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Upstream Bioprocessing Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.

Upstream Bioprocessing Industry Report

Statistics for the 2025 Upstream Bioprocessing market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Upstream Bioprocessing analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.

Upstream Bioprocessing Market Report Snapshots