Market Trends of Transthyretin Amyloidosis Treatment Industry
The Hereditary Transthyretin Amyloidosis Segment is Expected to Hold a Significant Share Over the Forecast Period
Hereditary transthyretin amyloidosis (hATTR) is a rare and severe, heterogeneous multisystem condition with prevalent peripheral (both somatic and autonomic) nervous system impairment due to mutations in the transthyretin (TTR) gene. Hereditary transthyretin amyloidosis (hATTR) is expected to hold a significant market share due to its hereditary characteristics, providing a consistent and identifiable patient base for targeted therapeutic endeavors. The factors driving the growth of this segment include growing awareness of hATTR through awareness programs, growing research investments, and market player strategies like partnerships, product approvals, and launches, which increase the availability of the products.
The increasing disease awareness significantly drives the segment growth as it increases the demand for effective treatments. As healthcare professionals and the general public become more informed about the symptoms, risk factors, and diagnostic advancement related to conditions, there is a growing emphasis on proactive management. For instance, in March 2024, Alnylam Pharmaceuticals Inc. launched the Family Health History Road Trip to encourage conversations between family members about their health history with their doctor to understand their risk for developing hereditary ATTR (hATTR) amyloidosis. This awareness helps in early diagnosis and treatment of the disease using various products, thereby boosting segment growth over the study period.
Furthermore, the strategies of market players, like partnerships and product approvals, increase the availability of the products in the market, thereby boosting segment growth. For instance, in January 2024, AstraZeneca and Ionis selected Orsini Specialty Pharmacy as the exclusive specialty pharmacy partner for WAINUA (eplontersen), an FDA-approved treatment for adults living with hereditary transthyretin-mediated amyloid polyneuropathy. In addition, in August 2022, Alnylam Pharmaceuticals Inc. stated that the FDA approved Onpattro, which can be used for nerve pain caused by hereditary transthyretin amyloidosis. These strategic activities are expected to increase the availability of the products and boost the segment growth over the forecast period.
Therefore, due to the growing awareness and strategic activities of market players, the hereditary transthyretin amyloidosis segment is expected to hold a significant market share over the forecast period.
North America is Expected to Record the Largest Share in the Market Over the Forecast Period
North America is expected to have the largest share in the market due to factors such as advanced healthcare infrastructure and the increasing incidence of transthyretin amyloidosis disease in the region. Established research capabilities, growing investments for research and development, and clinical trial infrastructure are driving the region's market growth.
New investments in developing advanced treatment products for transthyretin amyloidosis (ATTR) are expected to boost the market growth. For instance, in May 2023, the National Institutes of Health (NIH) awarded the Amyloidosis Research Consortium with USD 40,000 toward advancing ATTR amyloidosis drug development. These factors are expected to propel the market growth over the forecast period.
Additionally, growing market player strategies, such as product approvals and positive recommendations from the regulatory authorities, increase the usage of treatment products in the region. For instance, in April 2024, Alnylam Canada ULC received a positive recommendation for reimbursement from the Canadian Agency for Drugs and Technologies in Health (CADTH) for AMVUTTRA (vutrisiran injection). Similarly, in October 2023, AMVUTTRA was authorized for sale in Canada to treat stage 1 or stage 2 polyneuropathy in adult patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). Hence, the positive recommendations and approvals increase the usage and availability of products in the region, thereby boosting the region's market growth over the forecast period.
