| Study Period | 2019 - 2030 |
| Base Year For Estimation | 2024 |
| Forecast Data Period | 2025 - 2030 |
| Historical Data Period | 2019 - 2023 |
| CAGR | 6.90 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Tissue Sealants Market Analysis
The Global Tissue Sealants Market is expected to register a CAGR of 6.90% during the forecast period.
The impact of COVID in its initial phase was adverse owing to cancellations of elective procedures including orthopedic surgeries, which hampered the market growth. For instance, an article titled "Effect of COVID-19 Pandemic on Orthopedic Surgery in Three Centers from Romania" published in the International Journal of Environmental Research and Public Health in February 2021 stated that the orthopedic specialty was one of the most severely affected because of the significant number of elective surgeries that were postponed and major surgeries with high resource demands. The orthopedic departments were transformed into COVID-19 facilities, and joint replacements in particular were stopped worldwide. It also stated that in March 2020, the Surgeon General canceled all elective surgeries in the United States of America. Therefore, COVID-19 hindered the studied market. However, as the virus affected the bone and joints of the patient, it significantly affected the manufacturing of orthopedics implants, tools, instruments, and routine ongoing research and development which is expected to boost the market growth in coming years.
In addition, the rising prevalence of joint and bone disorders around the world, technological advancements in cartilage repair/regeneration, and the rapid increase in the geriatric population are actively affecting the growth of the studied market.
According to the Organization for Ecothe nomic Co-operation and Development, September 2022 update, total knee replacement surgery conducted in 2020 was 169,116 in Germany, 61,909 in Italy, and 30,808 in United Kingdom. The high burden of knee replacement surgeries worldwide is predicted to augment the growth of tissue sealants in the coming years.
Furthermore, according to World Population Prospects 2022 report, the percentage of the population aged 65 years and over in Sub-Saharan Africa is 3.0 in 2022 and projected to be 3.3 in 2030, in Northern Africa and Western Asia it is estimated to be 5.5 in 2022, and projected to be 7.0 in 2030, in Central and Southern Asia it is estimated to be 6.4 in 2022 and projected to be 8.1 in 2030, and in Europe and Northern America, 18.7 in 2022 and projected to be 22.0 in 2030. Since bone injuries are more common in the geriatric population, the growth of the market is likely to increase as the population increases.
Additionally, the engagement of key market players and institutions in research and development in the field of tissue sealants is expected to augment the market growth. For instance, a clinical trial titled "Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery" was commenced on August 2020 and completed on April 2022. The trial was sponsored by Polyganics BV in collaboration with University Hospital-Eppendorf (UKE) Hamburg. The objective of the study was to evaluate the sealing device's efficacy in preventing bile and pancreatic juice leakage during hepato-pancreato-biliary (HPB) surgery. The rising clinical trial activities for the development of innovative solutions are projected to augment the market growth.
The advancements in technology and increasing,g product approvals, along with partnerships and acquisitions by key players are helping in the market growth. For instance, in December 2021, BD (Becton, Dickinson and Company) acquired Tissuemed, Ltd., a privately held firm that is involved in developing self-adhesive surgical sealant films. Such developments are anticipated to augment the market growth.
Therefore, owing to the aforementioned factors the studied market is anticipated to witness growth over the analysis period. however, high costs of cartilage repair procedures and reimbursement issues are likely to impede the market growth.
Tissue Sealants Market Trends
Fibrin Sealants is Expected to Witness Growth Over the Forecast Period.
Fibrin sealants reconstruct the final phase of the blood coagulation cascade through the reaction of thrombin and fibrinogen at the wound spot to produce a cross-linked fibrin clot that stops bleeding. These products are generally indicated as an adjunct to hemostasis when control of bleeding by standard surgical techniques is ineffective or impractical. In orthopedic procedures, elective or urgent, bleeding is to be seriously considered, since usually both bones and soft tissues are injured or cut, so adapted hemostatic means have to be used.
According to the Organization for Economic Co-operation and Development, September 2022 update, coronary artery bypass graft surgical procedures conducted in Canada, France and Germany was 17,149, 16,389, and 38,859 respectively in 2020. The high prevalence of such cardiac surgeries is anticipated to boost the segment growth.
The advancements in technology and increasing product approvals, along with partnerships and acquisitions by key players are helping in the market growth. For instance, in February 2021, Takeda Pharmaceutical Company Limited sold TachoSil Fibrin Sealant Patch to Corza Health, Inc. Also, in January 2020 Terumo Corporation launched a new surgical sealant AQUABRID in Europe, the Middle East, and Africa Market. AQUABRID is a sealant specially developed for aortic surgeries. It reacts with blood and creates an elastic layer that adheres tightly to the tissue. Such developments are projected to augment the segments growth during the forecast period.
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North America is Expected to Dominate the Tissue Sealants Market Over the Forecast Period
North America is expected to dominate the market owing to factors such as the increase in the number of bone and sports injuries and rise in the number of hip and knee replacement surgeries, the growing geriatric population, the strong presence of industry players in the region, better healthcare infrastructure, awareness among people and healthcare industry stakeholders about available technologies, and the high concentration of market players in the region.
According to the Organization for Economic Co-operation and Development, September 2022 update, the total knee replacement surgery conducted was 54,918, and total hip replacement surgeries were 54,991 in Canada in 2020. The high burden of knee replacement surgeries and hip replacement surgeries is projected to boost the growth of tissue sealants in the region.
In addition, as per the Centers for Disease Control and Prevention 2021 report, each year, millions of older people (65 and older) fall in the United States. One out of five falls causes a serious injury such as broken bones. Each year, 3 million senior citizens are treated in emergency departments for fall injuries. It highlights that geriatric people are more prone to injury and hence this age group is more likely to need tissue sealants for treatment procedures.
Furthermore, as per the Statistics Canada, 2021 census, in Canada, there are around 7,021,430 people aged 65 years or above in 2021, out of which 3,224,680 are males and 3,796,750 are female. Such a large geriatric population in the country boost the possibility of high utility of tissue sealants in the region and thus boosts the growth of the market.
Therefore, owing to the above-mentioned factors, the growth of the studied market is anticipated in the North America Region.
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Tissue Sealants Industry Overview
The tissue sealants market is fragmented in nature due to the presence of many companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies which hold the market shares and are well known. Some of the key market players are Avin Darou, Grünenthal (Adhesys Medical Inc), Becton, Dickinson and Company, Baxter, Cohera Medical, CryoLife, Inc., CSL Behring, Johnson and Johnson Services, Inc. (Ethicon Inc.), Integra Lifesciences, and B. Braun SE among others.
Tissue Sealants Market Leaders
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CryoLife
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Integra LifeSciences Corporation
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Becton, Dickinson and Company
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Johnson and Johnson Services, Inc. (Ethicon Inc.)
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CSL Behring
- *Disclaimer: Major Players sorted in no particular order
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Tissue Sealants Market News
- April 2022: Ethicon, part of Johnson & Johnson launched Enseal X1 straight jaw tissue sealer for stronger sealing, greater efficiency, and easy access to targeted tissue in multiple surgical procedures.
- February 2022: Clariant launched 100% biobased surfactants, polyethylene glycols.
Tissue Sealants Industry Segmentation
As per the scope of the report, tissue sealants are agents with a clot-promoting activity that halts bleeding from injury or during surgery. The Tissue Sealants Market is segmented by Type of Sealant (Fibrin Sealants, Gelatin and Thrombin Mixtures, Polyethylene Glycol Polymers, Cyanoacrylates, Albumin, and Glutaraldehyde Tissue Sealants, and Other Types of Sealants), Application (Orthopedic, Cardiac Surgeries, Urology, Neuro Surgery, Dentistry, and Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.
| Type of Sealent | Fibrin Sealants | ||
| Gelatin and Thrombin Mixtures | |||
| Polyethylene Glycol Polymers | |||
| Cyanoacrylates | |||
| Albumin and Glutaraldehyde Tissue Sealants | |||
| Other Types of Sealants | |||
| Applications | Orthopeadic | ||
| Cardiac Surgeries | |||
| Urology | |||
| Neuro Surgery | |||
| Dentistry | |||
| Others | |||
| Geography | North America | United States | |
| Canada | |||
| Mexico | |||
| Europe | Germany | ||
| United Kingdom | |||
| France | |||
| Italy | |||
| Spain | |||
| Rest of Europe | |||
| Asia-Pacific | China | ||
| Japan | |||
| India | |||
| Australia | |||
| South Korea | |||
| Rest of Asia-Pacific | |||
| Middle East and Africa | GCC | ||
| South Africa | |||
| Rest of Middle East and Africa | |||
| South America | Brazil | ||
| Argentina | |||
| Rest of South America | |||
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Tissue Sealants Market Research FAQs
What is the current Global Tissue Sealants Market size?
The Global Tissue Sealants Market is projected to register a CAGR of 6.90% during the forecast period (2025-2030)
Who are the key players in Global Tissue Sealants Market?
CryoLife, Integra LifeSciences Corporation, Becton, Dickinson and Company, Johnson and Johnson Services, Inc. (Ethicon Inc.) and CSL Behring are the major companies operating in the Global Tissue Sealants Market.
Which is the fastest growing region in Global Tissue Sealants Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in Global Tissue Sealants Market?
In 2025, the North America accounts for the largest market share in Global Tissue Sealants Market.
What years does this Global Tissue Sealants Market cover?
The report covers the Global Tissue Sealants Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Global Tissue Sealants Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
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Tissue Sealants Industry Report
Statistics for the 2025 Global Tissue Sealants market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Global Tissue Sealants analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
