Restless Legs Syndrome Market Size
| Study Period | 2019-2029 |
| Market Size (2024) | USD 691.55 Million |
| Market Size (2029) | USD 891.44 Million |
| CAGR (2024 - 2029) | 5.21 % |
| Fastest Growing Market | Europe |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Restless Legs Syndrome Market Analysis
The Restless Legs Syndrome Market size is estimated at USD 691.55 million in 2024, and is expected to reach USD 891.44 million by 2029, growing at a CAGR of 5.21% during the forecast period (2024-2029).
During the pandemic period, the market witnessed a significant impact attributed to the increased burden of restless legs syndrome (RLS) in COVID-19-infected patients. For instance, as per the article published by the Journal of Clinical Sleep Medicine in May 2022, a study was conducted in the United States that showed that sleep disturbance was common in long-COVID-19 (LC) patients and RLS was often reported after the viral infection. This led to the increased demand for RLS treatment medications, which has further impacted the market growth during the pandemic period. However, the market is gradually stabilizing as COVID-19 cases declined to result in a return to the pre-pandemic level. Therefore, the COVID-19 pandemic accelerated the treatment of RLS and created lucrative opportunities for market growth in the studied period.
The rise in the prevalence of restless leg syndrome, the high unmet need for treatment, and the increasing geriatric population are key factors responsible for the market's growth. For instance, according to a study published by Frontiers Media S.A. in March 2022, the reported prevalence of restless legs syndrome varied between 3.9% and 14.3% globally. According to the same study, the prevalence of restless legs syndrome was higher among females than males. Thus, the high prevalence of RLS is expected to enhance market growth.
Furthermore, according to a study published in eClinicalMedicine in April 2022, about 25% of people with diabetes showed signs of restless legs syndrome, and people with diabetes had an increased risk of developing restless legs syndrome compared to people without diabetes. Also, according to the data published by the CDC, in June 2022, 37.3 million people in the United States had diabetes, which is approximately 11.3% of the United States population. Thus, the high prevalence of diabetes associated with restless leg syndrome is expected to drive market growth over the forecast period.
Additionally, various initiatives taken by the key market players, such as product launches, mergers, acquisitions, and partnerships, are expected to boost the market's growth during the forecast period. For instance, in April 2022, an East Carolina University researcher landed a licensing agreement with Clemens, a professor in the Brody School of Medicine's Department of Physiology, for a patent to treat restless legs syndrome and helped them secure the patent and an eventual licensing agreement with Emalex Biosciences. The partnership gave Emalex potential use for its D1 receptor antagonist, ecopipam. Such an initiative is expected to drive the growth of the market.
Thus, owing to the factors above, such as the high prevalence of restless legs syndrome and the rising initiatives by market players, the market studied is anticipated to grow over the analysis period. However, the side effects associated with restless syndrome treatments are expected to restrain the market's growth.
Restless Legs Syndrome Market Trends
Dopamine Agonists Segment is Expected to Hold a Significant Market Share Over the Forecast Period
Dopamine agonists are most often the first medicines used to treat RLS. These drugs, including pramipexole (Mirapex), rotigotine (Neupro), and ropinirole (Requip), act like the neurotransmitter dopamine in the brain. Factors such as the increase in the prevalence of restless legs syndrome and rising work-related stress caused due to pressure on the nervous system are expected to enhance the usage of dopamine agonists for the treatment of RLS. For instance, an article updated in October 2023 by the National Health Service (NHS) stated that 1 in 10 people are impacted by the restless legs syndrome in the United Kingdom every year, and women are more likely to develop the syndrome than men in the country. Additionally, 1 in 5 pregnant women develops the symptoms in the last trimester of their pregnancy. This leads to an increasing demand for its treatment, driving segmental growth.
Moreover, the increasing use of dopamine agonists for the treatment of restless leg syndrome is the key driver for the segment. For instance, according to the study published by the Nat Sci Sleep in October 2023, treatment with dopamine agonists is effective for up to 60.0% to 90.0% of affected individuals. Thus, such increasing use of dopamine agonists for the treatment of restless leg syndrome is expected to propel the segment growth.
Furthermore, the increase in product launches by the industry players is anticipated to drive the segment's growth. For instance, in July 2021, Ipsen and IRLAB reported signing a licensing agreement, providing Ipsen worldwide development and commercial rights to mesdopetam, a novel dopamine D3-receptor antagonist. Mesdopetam, an oral dopamine D3-receptor antagonist, has completed Phase Ib and IIa clinical programs. Such development is expected to increase the demand for segmental growth.
Thus, owing to the abovementioned factors, such as the high prevalence of RLS, the growing use of dopamine agonists for the treatment of RLS, and the increase in product launches by the industry players, the segment is expected to grow over the analysis period.
North America is Expected to Hold a Significant Share in the Market Over the Forecast Period
North America is expected to hold a significant market share in the restless legs syndrome market due to the region's rising prevalence of restless legs syndrome. For instance, according to an article published by the National Institutes of Health in February 2023, it was estimated that up to seven to 10% of the United States population have RLS, which can begin at any age. It occurs in males and females, although females are likelier to have it. Many severely affected individuals are middle-aged or older, and the symptoms typically become more frequent and last longer with age.
Similarly, as per the American Association of Neuromuscular & Electrodiagnostic Medicine report, in February 2022, about 12 million people in the United States had restless legs syndrome. Thus, with an increase in the prevalence of RLS, the demand for its treatment increases, thereby driving regional growth over the forecast period.
The increasing number of research programs is also expected to boost the studied market. For instance, Restless Legs Syndrome Foundation, Inc. awarded its 2023 RLS Research Grant to a researcher from the University of Toronto for its extensive research on using Canadian-approved cannabidiol/tetrahydrocannabinol topical oil to treat restless legs syndrome. The Canadian RLS Foundation funded the study. The Restless Legs Syndrome Foundation is highly expanding its reach in Canada and the United States, it has more than 70 groups and a network of remote support across Canada and the United States. The organization has also launched a Quality Care Center program to offer services and care to patients.
Therefore, the factors mentioned earlier, such as the high prevalence of RLS and growing research programs for RLS, will likely contribute to market growth over the forecast period in the North American region.
Restless Legs Syndrome Industry Overview
The restless legs syndrome market is moderately fragmented in nature due to the presence of several companies operating globally and regionally. The competitive landscape includes analyzing companies Azurity Pharmaceuticals, LLC, Glenmark Pharmaceutical, UCB S.A., Sun Pharmaceutical Industries Ltd, Boehringer Ingelheim International GmbH, Relegs, Restiffic, Viatris Inc., Psychocare Health Private Limited, and Noctrix Health, Inc. among others.
Restless Legs Syndrome Market Leaders
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UCB S.A
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Sun Pharmaceutical Industries Ltd
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Boehringer Ingelheim International GmbH
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Relegs
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Azurity Pharmaceuticals, LLC
*Disclaimer: Major Players sorted in no particular order
Restless Legs Syndrome Market News
- November 2023: Varco Leg Care, a consumer health-tech company, raised a bridge funding round of INR 2 Crore (USD 0.24 million) in the funding round led by the former CEO of Hindustan Coca-Cola, a blend of existing and new investors to advance its mission of revolutionizing leg care across India and the world. The company planned to expand its product portfolio with the introduction of unique topical phyto products for restless legs syndrome.
- April 2023: The United States Food and Drug Administration (FDA) approved de novo status for Noctrix Health’s NTX100 Tonic Motor Activation System for patients with restless legs syndrome. It was considered to be the first therapy to treat moderate to severe drug-refractory restless legs syndrome. The approval was based on the positive outcome of clinical trials. The product is a drug-free, wearable technology developed to activate leg muscles, reduce symptoms, and enhance sleep quality.
Restless Legs Syndrome Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Rise in Prevalence of Restless Leg Syndrome
4.2.2 High Unmet Need of Treatment and Increasing Geriatric Population
4.3 Market Restraints
4.3.1 Side Effects Associated with Restless Syndrome Treatments
4.4 Porter's Five Forces Analysis
4.4.1 Bargaining Power of Suppliers
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Threat of New Entrants
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
5.1 By Type
5.1.1 Primary Restless Legs Syndrome
5.1.2 Secondary Restless Legs Syndrome
5.2 By Treatment Type
5.2.1 Medication and Devices
5.2.1.1 Dopamine Agonists
5.2.1.2 Anti-seizure Agent
5.2.1.3 Benzodiazepines
5.2.1.4 Opioids
5.2.1.5 Other Treatment Types
5.2.2 Surgery
5.3 Geography
5.3.1 North America
5.3.1.1 United States
5.3.1.2 Canada
5.3.1.3 Mexico
5.3.2 Europe
5.3.2.1 Germany
5.3.2.2 United Kingdom
5.3.2.3 France
5.3.2.4 Italy
5.3.2.5 Spain
5.3.2.6 Rest of Europe
5.3.3 Asia-Pacific
5.3.3.1 China
5.3.3.2 Japan
5.3.3.3 India
5.3.3.4 Australia
5.3.3.5 South Korea
5.3.3.6 Rest of Asia-Pacific
5.3.4 Middle East and Africa
5.3.4.1 GCC
5.3.4.2 South Africa
5.3.4.3 Rest of Middle East and Africa
5.3.5 South America
5.3.5.1 Brazil
5.3.5.2 Argentina
5.3.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Azurity Pharmaceuticals, LLC
6.1.2 UCB S.A
6.1.3 Sun Pharmaceutical Industries Ltd
6.1.4 Boehringer Ingelheim International GmbH
6.1.5 Relegs
6.1.6 Restiffic
6.1.7 Viatris Inc
6.1.8 Psychocare Health Private Limited
6.1.9 Glenmark Pharmaceutical
6.1.10 Noctrix Health, Inc.
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Restless Legs Syndrome Industry Segmentation
As per the scope of the report, restless legs syndrome (RLS) is a situation that causes an uncontrollable urge to move the legs, usually because of an uncomfortable sensation.
The restless legs syndrome market is segmented by type (primary restless legs syndrome, secondary restless legs syndrome), treatment type (medicine and devices (dopamine antagonists, anti-seizure agents, benzodiazepines, opioids, and other treatment types), and surgery), and geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 countries across major regions globally.
The report offers the value (in USD) for the above segments.
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Restless Legs Syndrome Market Research FAQs
How big is the Restless Legs Syndrome Market?
The Restless Legs Syndrome Market size is expected to reach USD 691.55 million in 2024 and grow at a CAGR of 5.21% to reach USD 891.44 million by 2029.
What is the current Restless Legs Syndrome Market size?
In 2024, the Restless Legs Syndrome Market size is expected to reach USD 691.55 million.
Who are the key players in Restless Legs Syndrome Market?
UCB S.A, Sun Pharmaceutical Industries Ltd, Boehringer Ingelheim International GmbH, Relegs and Azurity Pharmaceuticals, LLC are the major companies operating in the Restless Legs Syndrome Market.
Which is the fastest growing region in Restless Legs Syndrome Market?
Europe is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Restless Legs Syndrome Market?
In 2024, the North America accounts for the largest market share in Restless Legs Syndrome Market.
What years does this Restless Legs Syndrome Market cover, and what was the market size in 2023?
In 2023, the Restless Legs Syndrome Market size was estimated at USD 655.52 million. The report covers the Restless Legs Syndrome Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Restless Legs Syndrome Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Restless Legs Syndrome Industry Report
Statistics for the 2024 Global Restless Legs Syndrome market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Global Restless Legs Syndrome analysis includes a market forecast outlook to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.
