Pruritus Therapeutic Market Size
| Study Period | 2019 - 2029 |
| Base Year For Estimation | 2023 |
| Forecast Data Period | 2024 - 2029 |
| CAGR (2024 - 2029) | 3.50 % |
| Fastest Growing Market | Asia-Pacific |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Pruritus Therapeutic Market Analysis
The Pruritus Therapeutics Market is expected to register a CAGR of 3.5% during the forecast period.
The impact of COVID-19 on the studied market was adverse in the initial phases owing to the cancellations of elective procedures, including treatment of pruritus, which impacted the studied market. For instance, as per the IJCED article, COVID-19 posed unique challenges for all healthcare specialists, including dermatologists, while treating skin conditions, including urticaria, a common dermatological condition. However, the market started to gain traction as treatment facilities and research and development activities to develop innovative therapeutics for pruritus by market players resumed worldwide.
The high prevalence of dermatological diseases like atopic dermatitis, urticaria, cutaneous T-cell, psoriasis, and allergic contact dermatitis and the introduction of novel products to treat the diseases are expected to propel the market growth. In addition, the increasing prevalence of dermatological disorders and the presence of high unmet needs are actively affecting the growth of the studied market.
As per the IJCM article, 20% of the Indian population had skin diseases in 2020. Infections and eczema accounted for two-thirds of the skin diseases in the study population. Also, as per the Life (Basel) Journal, the prevalence of atopic dermatitis was 34% from included studies among Swedish children in 2021. Thus, the high burden of atopic dermatitis or eczema is projected to boost the demand for pruritus therapeutics, as pruritus is an after-effect of these skin diseases.
Additionally, advancements in technology, increasing product approvals, partnerships, and acquisitions by key players are helping in the market growth. For instance, in August 2022, Chugai Pharmaceutical Co. Ltd subsidiary Maruho Co. Ltd launched the anti-IL-31 receptor - a humanized monoclonal antibody Mitchga subcutaneous injection of 60 mg syringes used to alleviate the itching brought on by atopic dermatitis. Mitchga was approved by the Ministry of Health, Labour, and Welfare (MHLW) in March 2022 and listed on the national health insurance (NHI) reimbursement price list in May 2022. Such advancements and developments are likely to boost the demand and usage of pruritus therapeutics in the upcoming year.
Therefore, owing to the aforementioned factors, the studied market is anticipated to witness growth over the analysis period. However, the lack of understanding of disease pathophysiology and the availability of advanced alternative treatment options is likely to impede the market growth.
Pruritus Therapeutic Market Trends
Corticosteroid Segment Expected to Hold Significant Share over the Forecast Period
Corticosteroids are the first-line drug for treating pruritus and are widely used to relieve atopic dermatitis or psoriasis. The segment is expected to witness growth during the forecast period. The increasing demand for over-the-counter topical corticosteroids is expected to be a potential driver for market growth in this segment.
The corticosteroid segment is expected to increase with the rising geriatric population since the aging population is more prone to chronic skin diseases such as atopic dermatitis and psoriasis. For instance, according to WPP, the population aged 65 years and over in sub-Saharan Africa is 3.0% in 2022 and projected to be 3.3% in 2030; in Northern Africa and Western Asia, it is estimated to be 5.5% in 2022 and projected to be 7.0% in 2030. In Central and Southern Asia, it is estimated to be 6.4% in 2022 and projected to be 8.1% in 2030, and in Europe and Northern America, 18.7% in 2022 and projected to be 22.0% in 2030. Since skin diseases are more common in the geriatric population, the growth of the segment is likely to increase as the population increases.
As per Frontiers, atopic dermatitis (AD) is one of the most frequent inflammatory skin diseases in humans, that affects up to 20% of children and 10% of adults in higher-income countries as of 2021. As of recently, topical corticosteroids (TCS) and calcineurin inhibitors (TCI) are the topical treatments available to treat mild to moderate AD. The high incidence of skin diseases like atopic dermatitis worldwide and the advantages of corticosteroids to treat them are ultimately estimated to augment segment growth.
North America Expected to Dominate the Pruritus Therapeutics Market over the Forecast Period
North America is expected to dominate the market owing to factors such as the rising incidence of dermatological diseases, the strong presence of industry players in the region, better healthcare infrastructure, and awareness among people and healthcare industry stakeholders about available technologies in the region.
The advancements in technology and increasing product approvals, along with collaborations and acquisitions by key players, are helping in the market growth. For instance, in August 2020, MC2 Therapeutics, a European company, collaborated with EPI Health, LLC for the co-commercialization of its Wynzora Cream in the US Market. Also, in July 2020, MC2 Therapeutics received Wynzora's USFDA approval for the treatment of Plaque Psoriasis in adults. In addition, MC2 Therapeutics is currently ongoing a phase 2 clinical trial of MC2-25 PAD cream for treating uremic pruritus.
Moreover, in June 2020, Cara Therapeutics, a clinical-stage biopharmaceutical company announced the successful completion of its Phase-II dose-ranging trial of oral Korsuva for moderate to severe chronic kidney disease-associated pruritus and is expected to fuel the competitiveness in the forecast period by its novel and proprietary class of product in the market. Such collaborations and clinical trial developments are anticipated to boost the market growth.
Rising clinical trial activities by market players for atopic dermatitis (AD) are anticipated to boost market growth, as severe AD is associated with pruritus. For instance, in August 2021, Eli Lilly and Company's ADvocate 1 and ADvocate 2 Phase 3 clinical trials showed positive results for lebrikizumab. The medication showed significant improvements, with at least 75% skin clearance in more than half of people with moderate-to-severe atopic dermatitis (AD). The United States Food and Drug Administration (FDA) has granted lebrikizumab (mAb) a fast-track designation for moderate-to-severe AD in adult and adolescent patients. Such developments are anticipated to boost the market growth in the region.
Pruritus Therapeutic Industry Overview
The pruritus therapeutics market is fragmented due to the presence of many companies operating globally and regionally. The competitive landscape includes an analysis of a few international and local companies that hold market shares and are well known. Some key players are Actavis, AbbVie Inc., Astellas Pharma Inc., Cara Therapeutics, EPI Health LLC, Galderma Laboratories LP, Ocera Therapeutics Inc., and Pfizer Inc., Sanofi, Trevi Therapeutics, among others.
Pruritus Therapeutic Market Leaders
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Cara Therapeutics
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EPI Health, LLC
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Gladerma Laboratories, LP.
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Sanofi SA
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AbbVie Inc.
*Disclaimer: Major Players sorted in no particular order
Pruritus Therapeutic Market News
- September 2022: Cara Therapeutics Inc. declared results from the KOMFORT Phase 2 clinical trial of oral difelikefalin for the treatment of moderate-to-severe pruritus in notalgia paresthetica (NP). The data of 125 patients with NP was presented at the 31st European Academy of Dermatology and Venereology (EADV) Congress.
- August 2022: Vifor Fresenius Medical Care Renal Pharma and Cara Therapeutics Inc. were granted marketing authorization by the European Commission for Kapruvia (difelikefalin) for the treatment of moderate-to-severe pruritus associated with chronic kidney disease (CKD) in adult hemodialysis patients.
Pruritus Therapeutic Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Increasing Prevalence of Dermatological Disorders
4.2.2 Presence of High Unmet Needs
4.3 Market Restraints
4.3.1 Lack of Understanding of Disease Pathophysiology
4.3.2 Availability of Advanced Alternative Treatment Options
4.4 Porter's Five Force Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD million)
5.1 By Product Type
5.1.1 Corticosteroid
5.1.2 Antihistamine
5.1.3 Local Anesthetic
5.1.4 Counterirritant
5.1.5 Immunosuppressant
5.1.6 Calcineurin Inhibitors
5.1.7 Other Product Types (Opioid Receptor Antagonists, Antidepressants and Antipruritics)
5.2 By Disease Type
5.2.1 Atopic Dermatitis/Eczema
5.2.2 Allergic Contact Dermatitis
5.2.3 Urticaria
5.2.4 Cutaneous T-cell
5.2.5 Other Disease Types (Cholestasis, Haematological, Neurological, Oncological, Renal and Drug Induced)
5.3 Geography
5.3.1 North America
5.3.1.1 United States
5.3.1.2 Canada
5.3.1.3 Mexico
5.3.2 Europe
5.3.2.1 Germany
5.3.2.2 United Kingdom
5.3.2.3 France
5.3.2.4 Italy
5.3.2.5 Spain
5.3.2.6 Rest of Europe
5.3.3 Asia-Pacific
5.3.3.1 China
5.3.3.2 Japan
5.3.3.3 India
5.3.3.4 Australia
5.3.3.5 South Korea
5.3.3.6 Rest of Asia-Pacific
5.3.4 Middle East and Africa
5.3.4.1 GCC
5.3.4.2 South Africa
5.3.4.3 Rest of Middle East and Africa
5.3.5 South America
5.3.5.1 Brazil
5.3.5.2 Argentina
5.3.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Actavis
6.1.2 AbbVie Inc.
6.1.3 Astellas Pharma Inc.
6.1.4 Cara Therapeutics
6.1.5 EPI Health LLC
6.1.6 Galderma Laboratories LP
6.1.7 Ocera Therapeutics Inc.
6.1.8 Pfizer Inc.
6.1.9 Sanofi
6.1.10 Trevi Therapeutics
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Pruritus Therapeutic Industry Segmentation
As per the scope of the report, pruritus is a condition of the skin accompanied by an unpleasant and irritating itching sensation over the skin that provokes scratching. Some chemical substances, like histamine, prostaglandins, proteases, substance P, and bile salts, may cause it. Sometimes accompanied by crusts, excoriations, hyperpigmentation, lichenification, pyoderma, increased skin creasing, and burnished nail.
The pruritus therapeutics market is expected to grow at a CAGR of 3.5% over the forecast period. The pruritus therapeutics market is segmented by product type (corticosteroid, antihistamine, local anesthetic, counterirritant, immunosuppressant, calcineurin inhibitors, and other product types), disease type (atopic dermatitis/eczema, allergic contact dermatitis, urticaria, cutaneous T-cell, and other disease types) and geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.
| By Product Type | |
| Corticosteroid | |
| Antihistamine | |
| Local Anesthetic | |
| Counterirritant | |
| Immunosuppressant | |
| Calcineurin Inhibitors | |
| Other Product Types (Opioid Receptor Antagonists, Antidepressants and Antipruritics) |
| By Disease Type | |
| Atopic Dermatitis/Eczema | |
| Allergic Contact Dermatitis | |
| Urticaria | |
| Cutaneous T-cell | |
| Other Disease Types (Cholestasis, Haematological, Neurological, Oncological, Renal and Drug Induced) |
| Geography | ||||||||
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Pruritus Therapeutic Market Research FAQs
What is the current Pruritus Therapeutics Market size?
The Pruritus Therapeutics Market is projected to register a CAGR of 3.5% during the forecast period (2024-2029)
Who are the key players in Pruritus Therapeutics Market?
Cara Therapeutics, EPI Health, LLC, Gladerma Laboratories, LP., Sanofi SA and AbbVie Inc. are the major companies operating in the Pruritus Therapeutics Market.
Which is the fastest growing region in Pruritus Therapeutics Market?
Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Pruritus Therapeutics Market?
In 2024, the North America accounts for the largest market share in Pruritus Therapeutics Market.
What years does this Pruritus Therapeutics Market cover?
The report covers the Pruritus Therapeutics Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Pruritus Therapeutics Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Pruritus Therapeutics Industry Report
Statistics for the 2024 Pruritus Therapeutics market share, size and revenue growth rate, created by Mordor Intelligenceā¢ Industry Reports. Pruritus Therapeutics analysis includes a market forecast outlook to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.
