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Plasma Protease C1-inhibitor Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)

The Plasma Protease C1-inhibitor Market is Segmented by Drug, Dosage Form (Lyophilized and Injectable), and Geography

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Plasma Protease C1-Inhibitor Market Size

CAGR
Study Period 2019 - 2029
Base Year For Estimation 2023
Forecast Data Period 2024 - 2029
CAGR 6.90 %
Fastest Growing Market Asia Pacific
Largest Market North America

Major Players

Plasma Protease C1-inhibitor Market

*Disclaimer: Major Players sorted in no particular order

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Plasma Protease C1-Inhibitor Market Analysis

The Plasma Protease C1-inhibitor Treatment Market is expected to experience a significant growth over the forecast period due to the growing incidence of hereditary angioedema (HAE). Hereditary angioedema is a potentially life-threatening genetic condition with incidence between 1 in 10,000 and 1 in 50,000 people according to HAE International (HAEi), the global umbrella organization for the world's HAE patient groups.

Additionally, increasing R&D investments, discovery of inhibitor drugs, increasing product approvals promising pipeline drugs and novel therapies for the treatment of hereditary angioedema are the few other factors driving the market globally.

Plasma Protease C1-Inhibitor Market Trends

This section covers the major market trends shaping the Plasma Protease C1-Inhibitor Market according to our research experts:

Selective Bradykinin B2 Receptor Antagonist Segment is Expected to Witness Healthy CAGR Over the Forecast Period

A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). In 2011, Icatibant (Firazyr), a selective bradykinin B2 receptor antagonist, was approved by the US Food and Drug Administration for treatment of acute attacks HAE in adults. Approval was based on 3 double-blind, randomized, controlled clinical trials known as For Angioedema Subcutaneous Treatment (FAST) 1, 2, and 3.

In September 2019, Pharvaris also received a USD 66 Million Series B Financing to Advance the Clinical Development of novel oral B2-receptor antagonists for the treatment of hereditary angioedema (HAE) and other B2-receptor-mediated indications.

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North America is Found Dominating the Global Plasma Protease C1-inhibitor Market

North America dominates the global Plasma Protease C1-inhibitor market owing to the rising Hereditary Angioedema (HAE) and increasing R&D investments. The other factors also includes presence of well-established healthcare infrastructure, an increasing number of product approvals, and major market players providing effective treatment options to the patients suffering from Hereditary Angioedema in North America.

According to DiscoverHAE, it is estimated that 6,000 people in the United States live with HAE currently. In June 2017, CSL Behring received U.S. Food and Drug Administration (FDA) approval for its HAEGARDA (C1 Esterase Inhibitor Subcutaneous [Human]), the first and only subcutaneous therapy indicated for routine prophylaxis to prevent hereditary angioedema (HAE) attacks in adolescent and adult patients. Hence all these factors are expected to drive the overall market in the United States.

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Plasma Protease C1-Inhibitor Industry Overview

In Plasma Protease C1-inhibitor market, major players are focusing on various market strategies such as high research and development activities, partnerships, collaborations, acquisitions and mergers etc. Major players in the Plasma Protease C1-inhibitor market are CSL Behring LLC., Takeda Pharmaceutical Company Limited, Pharming Technologies B.V., KalVista Pharmaceuticals, Inc amongst others.

Plasma Protease C1-Inhibitor Market Leaders

  1. CSL Behring LLC

  2. Takeda Pharmaceutical Company Limited (Shire Pharmaceutical Holdings)

  3. Pharming Technologies B.V.

  4. KalVista Pharmaceuticals, Inc.

  5. BioCryst Pharmaceuticals

*Disclaimer: Major Players sorted in no particular order

Picture1Plasma Protease C1-inhibitor Market
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Plasma Protease C1-Inhibitor Market Report - Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing Prevalence of Hereditary Angioedema (HAE)

      2. 4.2.2 Increasing Investments in the Research & Development Activities

    3. 4.3 Market Restraints

      1. 4.3.1 High Price of Esoteric Testing Procedures Restricting Market Entry

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 By Drug Type

      1. 5.1.1 C1-inhibitors

      2. 5.1.2 Kallikrein Inhibitor

      3. 5.1.3 Selective Bradykinin B2 Receptor Antagonist

    2. 5.2 By Dosage Form

      1. 5.2.1 Lyphophlised

      2. 5.2.2 Injectables

    3. 5.3 Geography

      1. 5.3.1 North America

        1. 5.3.1.1 United States

        2. 5.3.1.2 Canada

        3. 5.3.1.3 Mexico

      2. 5.3.2 Europe

        1. 5.3.2.1 Germany

        2. 5.3.2.2 United Kingdom

        3. 5.3.2.3 France

        4. 5.3.2.4 Italy

        5. 5.3.2.5 Spain

        6. 5.3.2.6 Rest of Europe

      3. 5.3.3 Asia Pacific

        1. 5.3.3.1 China

        2. 5.3.3.2 Japan

        3. 5.3.3.3 India

        4. 5.3.3.4 Australia

        5. 5.3.3.5 South Korea

        6. 5.3.3.6 Rest of Asia-Pacific

      4. 5.3.4 Middle East and Africa

        1. 5.3.4.1 GCC

        2. 5.3.4.2 South Africa

        3. 5.3.4.3 Rest of Middle East and Africa

      5. 5.3.5 South America

        1. 5.3.5.1 Brazil

        2. 5.3.5.2 Argentina

        3. 5.3.5.3 Rest of South America

  6. 6. COMPANY PROFILES AND COMPETITIVE LANDSCAPE

    1. 6.1 CSL Limited (CSL Behring LLC)

    2. 6.2 Takeda Pharmaceutical Company Limited (Shire Pharmaceutical Holdings)

    3. 6.3 Ionis Pharmaceuticals, Inc.

    4. 6.4 Pharming Technologies B.V.

    5. 6.5 Centogene AG

    6. 6.6 BioCryst Pharmaceuticals

    7. 6.7 KalVista Pharmaceuticals, Inc.

    8. 6.8 Fresenius Kabi

  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments
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Plasma Protease C1-Inhibitor Industry Segmentation

As per the scope of the report, plasma protease C1 inhibitor (C1 Inh) is a member of the serpin family of protease inhibitors and related proteins, and its mechanism of action is identical to those of the other protease inhibitor members of the family. SERPING1 forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases which will play a vital role in the regulation of blood coagulation, complement activation, generation of kinins and fibrinolysis. It is also an efficient FXIIa inhibitor. Mutations of the SERPING1 gene is associated with the adult macular degeneration which causes Hereditary Angioedema (HAE).

By Drug Type
C1-inhibitors
Kallikrein Inhibitor
Selective Bradykinin B2 Receptor Antagonist
By Dosage Form
Lyphophlised
Injectables
Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa
GCC
South Africa
Rest of Middle East and Africa
South America
Brazil
Argentina
Rest of South America
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Plasma Protease C1-Inhibitor Market Research FAQs

The Plasma Protease C1-inhibitor Market is projected to register a CAGR of 6.90% during the forecast period (2024-2029)

CSL Behring LLC, Takeda Pharmaceutical Company Limited (Shire Pharmaceutical Holdings), Pharming Technologies B.V., KalVista Pharmaceuticals, Inc. and BioCryst Pharmaceuticals are the major companies operating in the Plasma Protease C1-inhibitor Market.

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).

In 2024, the North America accounts for the largest market share in Plasma Protease C1-inhibitor Market.

The report covers the Plasma Protease C1-inhibitor Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Plasma Protease C1-inhibitor Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.

Plasma Protease C1-inhibitor Industry Report

Statistics for the 2024 Plasma Protease C1-inhibitor market share, size and revenue growth rate, created by Mordor Intelligenceā„¢ Industry Reports. Plasma Protease C1-inhibitor analysis includes a market forecast outlook to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.

Plasma Protease C1-inhibitor Report Snapshots

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Plasma Protease C1-inhibitor Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)