Phosphoramidite Market Size (2024 - 2029)

Phosphoramidite Market Analysis

The Phosphoramidite Market size is estimated at USD 1.13 billion in 2024, and is expected to reach USD 1.79 billion by 2029, growing at a CAGR of 6.42% during the forecast period (2024-2029).

At the start of the COVID-19 pandemic, most businesses and research activities around the world ceased due to the increasing rate of infection from the SARS-CoV-2 virus, which reduced the use and demand of gene synthesizers like phosphoramidite in laboratories in the market. However, gene synthesizers played a crucial role in the research and development of the mRNA-based COVID-19 vaccine, which eventually increased the demand for phosphoramidite in the market. For example, in January 2022, the Food and Drug Administration provided a second approval to the mRNA-based COVID-19 vaccine from Moderna called Spikevax. Therefore, such developments increased the demand for phosphoramidite during the pandemic.

• The factors responsible for the growth of the phosphoramidite market include increasing synthetic nucleotide applications in therapeutics, growth in synthetic biology, and therapeutics for different chronic diseases. Also, governments of various nations have been providing research support for synthetic biology because of its extensive applications. For instance, in September 2022, the Government of New South Wales announced an investment of over USD 6 million into a new synthetic biology and biomanufacturing development program, which would improve access to manufacturing and production facilities and equipment across the State of Wales, Australia.
• Furthermore, increasing product launches and approvals are expected to increase the demand for phosphoramidite synthesis, propelling the market growth. For instance, in June 2021, DNA Script launched the Syntax platform with its Syntax System, an Enzymatic DNA Synthesis (EDS) technology-powered benchtop nucleic acid printer. The Syntax System comprises up to 60 nucleotides in length and delivers ready-for-use in d genomics workflows and molecular biology without additional handling. The system enables DNA oligos to be printed on-demand at record speed and without the delays or backorders that can occur with outsourced phosphoramidite synthesis services. Such instances are expected to propel the market's growth over the forecast period.
• However, challenges in developing long nucleotide sequences are expected to hinder the market's growth.

Phosphoramidite Industry Segmentation

Phosphoramidites are modified nucleosides and are a standard chemical utilized in modern DNA synthesis. Phosphoramidites permit the sequential addition of new bases to the DNA chain in an exquisitely simple and exceptionally efficient cyclic reaction.

The phosphoramidite market is segmented by type, end-user, and geography. By type, the market is segmented into DNA phosphoramidites, RNA phosphoramidites, and other phosphoramidites. By end-user, the market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, and other end users. The report also covers the market sizes and forecasts for the phosphoramidite market in major countries across different regions. For each segment, the market size is provided in terms of value (USD).