| Study Period | 2019 - 2030 |
| Base Year For Estimation | 2024 |
| Market Size (2025) | USD 1.20 Billion |
| Market Size (2030) | USD 1.64 Billion |
| CAGR (2025 - 2030) | 6.42 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Phosphoramidite Market Analysis
The Phosphoramidite Market size is estimated at USD 1.20 billion in 2025, and is expected to reach USD 1.64 billion by 2030, at a CAGR of 6.42% during the forecast period (2025-2030).
At the start of the COVID-19 pandemic, most businesses and research activities around the world ceased due to the increasing rate of infection from the SARS-CoV-2 virus, which reduced the use and demand of gene synthesizers like phosphoramidite in laboratories in the market. However, gene synthesizers played a crucial role in the research and development of the mRNA-based COVID-19 vaccine, which eventually increased the demand for phosphoramidite in the market. For example, in January 2022, the Food and Drug Administration provided a second approval to the mRNA-based COVID-19 vaccine from Moderna called Spikevax. Therefore, such developments increased the demand for phosphoramidite during the pandemic.
- The factors responsible for the growth of the phosphoramidite market include increasing synthetic nucleotide applications in therapeutics, growth in synthetic biology, and therapeutics for different chronic diseases. Also, governments of various nations have been providing research support for synthetic biology because of its extensive applications. For instance, in September 2022, the Government of New South Wales announced an investment of over USD 6 million into a new synthetic biology and biomanufacturing development program, which would improve access to manufacturing and production facilities and equipment across the State of Wales, Australia.
- Furthermore, increasing product launches and approvals are expected to increase the demand for phosphoramidite synthesis, propelling the market growth. For instance, in June 2021, DNA Script launched the Syntax platform with its Syntax System, an Enzymatic DNA Synthesis (EDS) technology-powered benchtop nucleic acid printer. The Syntax System comprises up to 60 nucleotides in length and delivers ready-for-use in d genomics workflows and molecular biology without additional handling. The system enables DNA oligos to be printed on-demand at record speed and without the delays or backorders that can occur with outsourced phosphoramidite synthesis services. Such instances are expected to propel the market's growth over the forecast period.
- However, challenges in developing long nucleotide sequences are expected to hinder the market's growth.
Phosphoramidite Market Trends
DNA Phosphoramidites is Expected to Witness Growth Over the Forecast Period
- Phosphoramidites are standard chemical and amodified nucleosides used in modern DNA synthesis. These molecules allow the sequential addition of new bases to the DNA chain in an exquisitely simple and exceptionally efficient cyclic reaction.
- The increasing use of next-generation sequencing technology in several applications, such as biomarker discovery, oncology studies, and personalized medicine, is the key factor driving the market growth. For instance, the fast emergence of next-generation sequencing technology has revolutionized the field of genomics and medical diagnosis and has changed the traditional model of a gene-by-gene approach to syndrome-based panel sequencing, diagnostic exome sequencing (DES), and diagnostic genome sequencing (DGS), and precision model. According to the Centers for Disease Control and Prevention (CDC), in 2021, it is projected that more than 60 million people will have their genomes sequenced by 2025 worldwide as countries have taken the initiative to sequence large populations.
- Moreover, various companies are developing different ways to utilize phosphoramidite for oligonucleotide synthesis, which are expected to increase their adoption in the pharmaceutical and biotechnology industry, bolstering market growth. For instance, in June 2022, Amerigo Scientific launched extra large Drying Traps (up to 4 liters of acetonitrile solution) for research applications. These new DNA moisture traps can be used for maintaining moisture-free environments in oligonucleotide synthesis. These traps efficiently dry phosphoramidite solutions in acetonitrile, tetrazole solutions in acetonitrile (activator solutions), or dry acetonitrile (for preparing phosphoramidite solutions or activator solutions).
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North America is Expected to Dominate the Market Over the Forecast Period
- The increasing number of investments by the government, advancements in research and development about NGS, and the growing prevalence of target diseases are expected to drive market growth in North America. The rising funding by research institutes, companies, and universities for next-generation sequencing is contributing to the growth of the market in the region. For instance, in August 2022, the Department of Health and Human Services announced funding for innovative research and study of structural birth defects with the use of human translational/clinical approaches (genomics, metabolomics, proteomics, etc.) and animal models.
- Moreover, the rising focus of companies on research and development activities, as well as the rising adoption of various business strategies such as product launches, partnerships, collaborations, and acquisitions, are also contributing to the market's growth. For instance, In May 2022, TriLink BioTechnologies announced a cooperative agreement with the Department of Defense and included funding for TriLink's expansion in San Diego, California, for nucleic acid production.
- Thus, the market is expected to witness significant growth over the forecast period due to the above-mentioned developments.
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Phosphoramidite Industry Overview
The phosphoramide market is moderately competitive and consists of several major players. In terms of market share, a few of the major players Thermo Fisher Scientific, Biosynth Carbosynth, TriLink BioTechnologies, Bioneer Corporation, Hongene Biotech Corporation and others, are currently dominating the industry.
Phosphoramidite Market Leaders
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Thermo Fisher Scientific
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Biosynth Carbosynth
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TriLink BioTechnologies
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Bioneer Corporation
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Hongene Biotech Corporation
- *Disclaimer: Major Players sorted in no particular order
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Phosphoramidite Market News
- March 2023: Oligo Factory, an independent custom oligonucleotide manufacturer, opened a new oligo manufacturing facility with 13,000 sq ft of combined offices, bench space, and labs in Holliston, United States.
- July 2022: WuXi STA launched a new large-scale oligonucleotide and peptide manufacturing facility at its Changzhou campus. This new launch enhances its capacity and capability to meet the fast-growing customer needs for oligonucleotide and peptide therapeutics development and manufacturing worldwide.
Phosphoramidite Industry Segmentation
Phosphoramidites are modified nucleosides and are a standard chemical utilized in modern DNA synthesis. Phosphoramidites permit the sequential addition of new bases to the DNA chain in an exquisitely simple and exceptionally efficient cyclic reaction.
The phosphoramidite market is segmented by type, end-user, and geography. By type, the market is segmented into DNA phosphoramidites, RNA phosphoramidites, and other phosphoramidites. By end-user, the market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, and other end users. The report also covers the market sizes and forecasts for the phosphoramidite market in major countries across different regions. For each segment, the market size is provided in terms of value (USD).
| By Type | DNA Phosphoramidites | |
| RNA Phosphoramidites | ||
| Other Phosphoramidites | ||
| By End-User | Pharmaceutical and Biotechnology Companies | |
| Academic and Research Institutes | ||
| Other End-Users | ||
| Geography | North America | United States |
| Canada | ||
| Mexico | ||
| Geography | Europe | Germany |
| United Kingdom | ||
| France | ||
| Italy | ||
| Spain | ||
| Rest of Europe | ||
| Geography | Asia-Pacific | China |
| Japan | ||
| India | ||
| Australia | ||
| South Korea | ||
| Rest of Asia-Pacific | ||
| Geography | Rest of the World |
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Phosphoramidite Market Research Faqs
How big is the Phosphoramidite Market?
The Phosphoramidite Market size is expected to reach USD 1.20 billion in 2025 and grow at a CAGR of 6.42% to reach USD 1.64 billion by 2030.
What is the current Phosphoramidite Market size?
In 2025, the Phosphoramidite Market size is expected to reach USD 1.20 billion.
Who are the key players in Phosphoramidite Market?
Thermo Fisher Scientific, Biosynth Carbosynth, TriLink BioTechnologies, Bioneer Corporation and Hongene Biotech Corporation are the major companies operating in the Phosphoramidite Market.
Which is the fastest growing region in Phosphoramidite Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in Phosphoramidite Market?
In 2025, the North America accounts for the largest market share in Phosphoramidite Market.
What years does this Phosphoramidite Market cover, and what was the market size in 2024?
In 2024, the Phosphoramidite Market size was estimated at USD 1.12 billion. The report covers the Phosphoramidite Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Phosphoramidite Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
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Phosphoramidite Industry Report
Statistics for the 2025 Phosphoramidite market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Phosphoramidite analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
