Knock Out Mouse Model Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 1.37 Billion |
| Market Size (2029) | USD 1.79 Billion |
| CAGR (2024 - 2029) | 5.20 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
| Market Concentration | Medium |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Knock Out Mouse Model Market Analysis
The Knock Out Mouse Model Market size is estimated at USD 1.37 billion in 2024, and is expected to reach USD 1.79 billion by 2029, growing at a CAGR of 5.20% during the forecast period (2024-2029).
During the COVID-19 pandemic, the knockout mouse model market was significantly impacted due to the wide usage of these models in COVID-19-related studies. Furthermore, the continued studies on COVID-19 in laboratories using the knockout mouse model are expected to continue growth over the coming period. For instance, as per the report published by eBioMedicine in December 2021, the suppression of NLRP3 inflammasome by genetic knockout and specific inhibitors in the mouse models consistently displayed its immune importance in COVID-19 disease progression. It showed the importance of the knockout mouse model in COVID-19 research, which is expected to boost the market over the coming years.
Factors driving the knockout mouse model market growth include the increasing development of novel and innovative drugs and medical devices, rising demand for personalized medicine, and advancements in gene editing tools. Additionally, the knockout mouse model market is expanding with increased R&D activities in pharmaceutical industries. For instance, in May 2021, Taysha Gene Therapies, Inc. published new preclinical data for TSHA-102 in Rett syndrome. TSHA-102 resulted in a statistically significant survival extension by 56% in 4-5-week-old knockout Rett mice with meaningful accumulated disease. In contrast, unregulated constructs did not extend survival significantly in the validated MECP2 knockout Rett mouse model. It shows the wide usage of knockout mouse models in various research studies.
For instance, as per the report published by Cyagen Biosciences in April 2021, the knockout mouse model is a crucial resource for drug development. To greatly increase pertinent insights into innovative diagnostic and therapeutic methods, heterozygous and homozygous knockout lines are frequently used in human disease research, such as for investigations of rare diseases and developmental disorders. These widespread applications of knockout mouse models in the pharmaceutical industry are expected to include significant growth in the market over the forecast period.
The strategic activities by the market players is expected to boost the market over the forecast period. For instance, in October 2022, Taconic Biosciences launched the FcResolv NOG portfolio, the super immunodeficient mouse model with a knockout of murine Fc gamma receptors (FcγRs). It is known to confound results in antibody-based therapy studies. Additionally, in August 2022, the University of California, Davis, awarded just over USD 12 million from the NIH under the third and final five-year phase of the Knockout Mouse Phenotyping Project, or KOMP2. This final phase of KOMP2 aims to produce and phenotype hundreds of knockout mouse models for genes with little to no known function to better understand the genetic bases for diseases in humans and animals.
However, alternatives to animal testing and regulations for the ethical use of animals are the major factors restraining the growth of the knockout mouse model market over the forecast period.
Knock Out Mouse Model Market Trends
Conditional Knockout Mouse Segment is Expected to Hold Significant Share in the Market Over the Forecast Period
In conditional knockout mice, a gene is inactivated in a specific tissue to study the function of individual genes and model human diseases. Due to the various advantages of conditional knockout mouse models over other models, the segment is expected to include significant growth in the market. The rising pharmaceutical investment and expenditure and strategic initiatives adopted by the market players are augmenting the demand for conditional knockout mouse models, contributing to the market growth.
For instance, as per the report published by Cyagen Biosciences in April 2021, conditional models offer greater temporal and regional control of gene expression than constitutively expressed gene mutations, making them a more accurate model for researching human diseases. It shows the added advantages of conditional models over other models, which increases the usage of these models and is expected to boost the growth of the segment in the market.
Furthermore, the increasing usage of conditional knockout mouse models in research and development is expected to drive the market. For instance, as per the study report published by iScience in July 2021, conditional knockout (cKO) of Celsr3 in postnatal Purkinje cells of mice exhibited a deficit in motor coordination and learning, atrophic Purkinje cell dendrites, and decreased synapses. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells. These studies help in various types of research, which likely propel the market over the study period.
North America is Expected to include Significant Share in Market Over the Forecast Period
North America is expected to include a significant share in the market with its well-established healthcare infrastructure, better regulatory framework, and government support and presence of many large biotechnological and biopharmaceutical firms in developed countries like the United States and Canada. In addition, the rising demand for personalized medicine research activities is expected to boost the market to grow in the region.
For instance, in July 2022, Tenaya Therapeutics, Inc. published the preclinical research data in Science Translational Medicine detailing the discovery of HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy. To further validate the potential of HDAC6 inhibition, Tenaya translated its initial in vitro findings to a BAG3 cardiomyocyte knockout mouse model of dilated cardiomyopathy. It shows the new application of the knockout mouse model, which increases the usage of the model and is expected to boost the market over the forecast period.
Similarly, the approval of these models for clinical development is expected to drive the market. For instance, in March 2022, Taysha Gene Therapies, Inc. initiated the clinical development of TSHA-102 for treating Rett syndrome under an approved Clinical Trial Application (CTA) by Health Canada. The pharmacologic activity of TSHA-102 following intrathecal (IT) administration was assessed in the MECP2 knockout mouse model of Rett syndrome across three dose levels and three age groups. Thus, these models' new research activities and approvals are expected to boost market growth over the forecast period.
Knock Out Mouse Model Industry Overview
The knockout mouse model market is moderately competitive with the presence of number of market players. It comprises a network of players involved in research and product development, component manufacturing, distribution and sales, and post-sale services. Some of the major players in the market are Envigo, GenOway, Cyagen Biosciences, Charles River Laboratories, Trans Genic Inc., and others.
Knock Out Mouse Model Market Leaders
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Envigo
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genOway
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Cyagen Biosciences
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Charles River Laboratories
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Trans Genic Inc
*Disclaimer: Major Players sorted in no particular order
Knock Out Mouse Model Market News
- In September 2023, Biocytogen Pharmaceuticals (Beijing) Co., Ltd. announced the RenMice series, which includes a collection of independently developed, fully human antibody mice and TCR mice with proprietary intellectual property.
- In August 2023, GemPharmatech announced the launch of NeoMab independently developed fully antibody gene humanized mouse model. NeoMab is specifically designed to meet the burgeoning therapeutic antibody development demands of biotechnology companies and pharmaceutical enterprises.
Knock Out Mouse Model Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions & Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Rise in the Advancements of Gene Editing Tools
4.2.2 Growing Research and Development activities by Pharmaceutical and Biopharmaceutical Companies
4.2.3 Rising Demand for Personalized Medicine
4.3 Market Restraints
4.3.1 Alternatives to Animal Testing
4.3.2 Regulations for the Ethical Use of Animals
4.4 Porter's Five Forces Analysis
4.4.1 Bargaining Power of Suppliers
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Threat of New Entrants
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
5.1 By Type
5.1.1 Constitutive Knockout Mouse
5.1.2 Conditional Knockout Mouse
5.1.3 Protein Function Knockout Mouse
5.2 By Application
5.2.1 Oncology
5.2.2 Neurology
5.2.3 Cardiovascular
5.2.4 Other Applications
5.3 By End-User
5.3.1 Clinical Research Organizations
5.3.2 Pharma & Biotechnology Companies
5.3.3 Others
5.4 Geography
5.4.1 North America
5.4.1.1 United States
5.4.1.2 Canada
5.4.1.3 Mexico
5.4.2 Europe
5.4.2.1 Germany
5.4.2.2 United Kingdom
5.4.2.3 France
5.4.2.4 Italy
5.4.2.5 Spain
5.4.2.6 Rest of Europe
5.4.3 Asia-Pacific
5.4.3.1 China
5.4.3.2 Japan
5.4.3.3 India
5.4.3.4 Australia
5.4.3.5 South Korea
5.4.3.6 Rest of Asia-Pacific
5.4.4 Middle East and Africa
5.4.4.1 GCC
5.4.4.2 South Africa
5.4.4.3 Rest of Middle East and Africa
5.4.5 South America
5.4.5.1 Brazil
5.4.5.2 Argentina
5.4.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Charles River Laboratories
6.1.2 Cyagen Biosciences
6.1.3 Envigo
6.1.4 genOway
6.1.5 Ozgene Pty Ltd.
6.1.6 Taconic Biosciences, Inc.
6.1.7 The Jackson Laboratory
6.1.8 Trans Genic Inc
6.1.9 Ingenious Targeting Laboratory
6.1.10 Ximbio
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Knock Out Mouse Model Industry Segmentation
As per the scope of the report, a knockout mouse is a laboratory mouse in which one or more genes are turned off or knocked out. To develop a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. Knockout mice study alterations and functions in an organism when a particular gene is absent. The Knockout Mouse Model Market is segmented by type (constitutive knockout mouse, conditional knockout mouse, and protein function knockout mouse), application (oncology, neurology, cardiovascular, and other applications), end-user (clinical research organizations, pharma and biotechnology companies, and others) and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD) for the above segments.
| By Type | |
| Constitutive Knockout Mouse | |
| Conditional Knockout Mouse | |
| Protein Function Knockout Mouse |
| By Application | |
| Oncology | |
| Neurology | |
| Cardiovascular | |
| Other Applications |
| By End-User | |
| Clinical Research Organizations | |
| Pharma & Biotechnology Companies | |
| Others |
| Geography | ||||||||
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Knock Out Mouse Model Market Research Faqs
How big is the Knock Out Mouse Model Market?
The Knock Out Mouse Model Market size is expected to reach USD 1.37 billion in 2024 and grow at a CAGR of 5.20% to reach USD 1.79 billion by 2029.
What is the current Knock Out Mouse Model Market size?
In 2024, the Knock Out Mouse Model Market size is expected to reach USD 1.37 billion.
Who are the key players in Knock Out Mouse Model Market?
Envigo, genOway, Cyagen Biosciences, Charles River Laboratories and Trans Genic Inc are the major companies operating in the Knock Out Mouse Model Market.
Which is the fastest growing region in Knock Out Mouse Model Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Knock Out Mouse Model Market?
In 2024, the North America accounts for the largest market share in Knock Out Mouse Model Market.
What years does this Knock Out Mouse Model Market cover, and what was the market size in 2023?
In 2023, the Knock Out Mouse Model Market size was estimated at USD 1.30 billion. The report covers the Knock Out Mouse Model Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Knock Out Mouse Model Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Knock Out Mouse Model Industry Report
Statistics for the 2024 Knock Out Mouse Model market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Knock Out Mouse Model analysis includes a market forecast outlook to for 2024 to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.
Knock Out Mouse Model Market Report Snapshots
