Inhaled Nitric Oxide Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The report covers Global Inhaled Nitric Oxide Manufacturers and the market is segmented by Product Type (Gas and Delivery Systems), Application (Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Other Applications), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Inhaled Nitric Oxide Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

Inhaled Nitric Oxide Market Size

Inhaled Nitric Oxide Market  Summary
Study Period 2021 - 2030
Base Year For Estimation 2024
Forecast Data Period 2025 - 2030
CAGR 4.60 %
Fastest Growing Market Asia Pacific
Largest Market North America
Market Concentration Low

Major Players

Inhaled Nitric Oxide Market  Major Players

*Disclaimer: Major Players sorted in no particular order

Compare market size and growth of Inhaled Nitric Oxide Market with other markets in Healthcare Industry

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Inhaled Nitric Oxide Market Analysis

The Inhaled Nitric Oxide Market is expected to register a CAGR of 4.6% during the forecast period.

The COVID-19 pandemic has impacted the global healthcare system, including the inhaled nitric oxide market. For instance, an article published in the journal IJP in May 2021 reported that in patients with COVID-19 with acute respiratory distress syndrome (ARDS), nitric oxide was linked to a slight increase in oxygenation. Initially, the market witnessed significant growth due to the rising number of COVID-19 cases, and the significant effect of liquid nitric oxide was linked to overcoming ARDS in COVID-19 patients by increasing arterial oxygenation. Now that COVID-19 cases have declined, it is anticipated that the demand for inhaled nitric oxide may stabilize.

The factors driving the growth of this market are the rising prevalence of respiratory and other associated diseases and ongoing research and development activities. The most prevalent element driving this market is rising cases of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute respiratory disease syndrome (ARDS), and tuberculosis (TB), among others.

Asthma and COPD are considered the most common chronic disease worldwide and this has driven the need for inhaled nitric oxide. For instance, in August 2022, Lung India reported that the prevalence of Asthma among Indian children was around 18.2%. The same source suggests that there is a high prevalence of severe asthma in the emerging markets of the Middle East and Africa as well as Latin America, compared to the mid-range prevalence in North America and Europe.

Similarly, the rising cases of malaria reported globally are increasing the demand for inhaled nitric oxide. The inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain and enhances survival in cerebral malaria cases. In July 2022, WHO reported that in the year 2020, 241 million cases of malaria were estimated globally.

The ongoing research and development activities and clinical trials being conducted for the development of new drugs to prevent this disease are also expected to fuel the market growth. For instance, in February 2022, Glenmark launched a nitric oxide nasal spray (FabiSpray) in India for the treatment of adult patients with COVID-19 in partnership with SaNOtize.

While these factors are poised to give the market an impetus, strict application norms across various regions may slow down its growth over the studied period.

Inhaled Nitric Oxide Industry Overview

The inhaled nitric oxide market is competitive due to the presence of many companies operating globally and regionally. The competitive landscape includes an analysis of a few international as well as local companies which hold market shares and are well-known, such as Air Liquide Healthcare, Matheson Tri-Gas Inc., Merck KGaA, Mallinckrodt Pharmaceuticals (Novoteris), BOC Healthcare, Nu-Med Plus Inc., Perma Pure LLC, Praxair Distribution Inc., HALMA PLC, LINDE PLC, and Bellerophan Therapeutics Inc.

Inhaled Nitric Oxide Market Leaders

  1. Bellerophan Therapeutics Inc.

  2. Mallinckrodt Pharmaceuticals (Novoteris)

  3. Merck KGaA

  4. Linde Plc

  5. BOC Healthcare

  6. *Disclaimer: Major Players sorted in no particular order
Inhaled Nitric Oxide Market Concentration
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Inhaled Nitric Oxide Market News

  • In August 2022, Zylo Therapeutics Inc. was awarded a two-year USD 600,000 Small Business Innovation Research (SBIR) grant for generating its final formulation of Zylö's proprietary nitric oxide-releasing topical drug for the treatment of onychomycosis. The grant is sponsored by the National Institute of Allergy and Infectious Diseases, a division of the National Institute of Health (NIH).
  • In August 2022, SaNOtize Research & Development Corp. received an oversubscribed USD 24 million Series B funding to advance its nitric oxide-based therapeutics pipeline. The lead treatment in the pipeline is the company's nitric oxide nasal spray (NONS), which has been shown in clinical studies to treat and prevent COVID-19 infection.

Inhaled Nitric Oxide Market Report - Table of Contents

1. INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2. RESEARCH METHODOLOGY

3. EXECUTIVE SUMMARY

4. MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising Prevalence of Respiratory and Other Associated Diseases
    • 4.2.2 Ongoing Research and Development Activities
  • 4.3 Market Restraints
    • 4.3.1 Strict Application Norms across Various Regions
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5. MARKET SEGMENTATION (Market Size by Value - USD million)

  • 5.1 By Product Type
    • 5.1.1 Gas
    • 5.1.2 Delivery Systems
  • 5.2 By Application
    • 5.2.1 Neonatal Respiratory Treatment
    • 5.2.2 Asthma and COPD
    • 5.2.3 Acute Respiratory Distress Syndrome
    • 5.2.4 Malaria Treatment
    • 5.2.5 Tuberculosis Treatment
    • 5.2.6 Other Applications
  • 5.3 Geography
    • 5.3.1 North America
    • 5.3.1.1 United States
    • 5.3.1.2 Canada
    • 5.3.1.3 Mexico
    • 5.3.2 Europe
    • 5.3.2.1 Germany
    • 5.3.2.2 United Kingdom
    • 5.3.2.3 France
    • 5.3.2.4 Italy
    • 5.3.2.5 Spain
    • 5.3.2.6 Rest of Europe
    • 5.3.3 Asia-Pacific
    • 5.3.3.1 China
    • 5.3.3.2 Japan
    • 5.3.3.3 India
    • 5.3.3.4 Australia
    • 5.3.3.5 South Korea
    • 5.3.3.6 Rest of Asia-Pacific
    • 5.3.4 Middle East and Africa
    • 5.3.4.1 GCC
    • 5.3.4.2 South Africa
    • 5.3.4.3 Rest of Middle East and Africa
    • 5.3.5 South America
    • 5.3.5.1 Brazil
    • 5.3.5.2 Argentina
    • 5.3.5.3 Rest of South America

6. COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Air Liquide Healthcare
    • 6.1.2 BOC Healthcare
    • 6.1.3 Matheson Tri-Gas Inc.
    • 6.1.4 Merck KGaA
    • 6.1.5 Mallinckrodt Pharmaceuticals (Novoteris)
    • 6.1.6 Nu-Med Plus Inc.
    • 6.1.7 Perma Pure LLC
    • 6.1.8 Praxair Distribution Inc.
    • 6.1.9 HALMA PLC
    • 6.1.10 LINDE PLC
    • 6.1.11 Bellerophan Therapeutics Inc.
  • *List Not Exhaustive

7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Inhaled Nitric Oxide Industry Segmentation

Nitric oxide is a gas that is inhaled, and it works by relaxing smooth muscles to dilate blood vessels, especially in the lungs. The gas is mainly used in a breathing machine (ventilator) to treat respiratory failure in premature babies and treat COPD and ARDS. The Inhaled Nitric Oxide Market is segmented by Product Type (Gas and Delivery Systems), Application (Neonatal Respiratory Treatment, Asthma and COPD, Acute Respiratory Distress Syndrome, Malaria Treatment, Tuberculosis Treatment, and Other Applications), and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD million) for the above segments.

By Product Type Gas
Delivery Systems
By Application Neonatal Respiratory Treatment
Asthma and COPD
Acute Respiratory Distress Syndrome
Malaria Treatment
Tuberculosis Treatment
Other Applications
Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
South America Brazil
Argentina
Rest of South America
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Inhaled Nitric Oxide Market Research FAQs

What is the current Inhaled Nitric Oxide Market size?

The Inhaled Nitric Oxide Market is projected to register a CAGR of 4.6% during the forecast period (2025-2030)

Who are the key players in Inhaled Nitric Oxide Market?

Bellerophan Therapeutics Inc., Mallinckrodt Pharmaceuticals (Novoteris), Merck KGaA, Linde Plc and BOC Healthcare are the major companies operating in the Inhaled Nitric Oxide Market.

Which is the fastest growing region in Inhaled Nitric Oxide Market?

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Which region has the biggest share in Inhaled Nitric Oxide Market?

In 2025, the North America accounts for the largest market share in Inhaled Nitric Oxide Market.

What years does this Inhaled Nitric Oxide Market cover?

The report covers the Inhaled Nitric Oxide Market historical market size for years: 2021, 2022, 2023 and 2024. The report also forecasts the Inhaled Nitric Oxide Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.

Depth Filtration Industry Report

Statistics for the 2025 Inhaled Nitric Oxide market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Inhaled Nitric Oxide analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.