Market Trends of Global In Silico Clinical Trials Industry
This section covers the major market trends shaping the In Silico Clinical Trials Market according to our research experts:
Oncology Therapeutic Area is Expected to Witness a Significant Growth Over the Forecast Period
Regular cancer clinical trials are mostly at a high cost and have a significant risk of causing harm to patients. The demand for cancer in silico clinical trials is mostly driven by these considerations. Furthermore, technological advancements such as using artificial intelligence (AI) in cancer computer simulation studies to improve medication knowledge, safety, and efficacy are boosting the market's growth.
As per the news published in In silico Medicine in 2022, they announced they had completed experimental validation of AI-designed compounds with the requisite features and have nominated a preclinical candidate (PCC) for anti-cancer therapeutics targeting ubiquitin-specific protease 1 (USP1), a known synthetic lethality target. Synthetic lethality, a well-established genetic technique to exploit vulnerabilities in tumor cells to trigger tumor cell death while sparing normal cells, is a potential field of cancer therapy. When used against a wide spectrum of tumor lineages, Insilico's preclinical candidate molecule showed promising results. In vitro studies revealed that the chemical has a substantial antiproliferative effect in breast cancer gene mutant (BRCA) tumor cells with high selectivity.
The article published in MedRxiv journal under the heading "In silico cancer immunotherapy trials uncovers the consequences of therapy-specific response patterns for clinical trial design and outcome" in 2021 explains the advantages of cancer immunotherapy coupled with in silico trials. In the study, they point out that, for immuno-oncology, in silico studies have major implications. They offer a cost-effective way to check the validity of the biological assumptions that underpin immunotherapy trials and aid in their design. It can also be used as a teaching tool that can help scientists in training understand design principles, resulting in better designs and higher success rates in future immunotherapy studies.
As a result of the stated factors, the oncology therapeutic area segment is expected to develop significantly throughout the forecast period.
North America is Expected to Grow the In Silico Clinical Trials Market
North America had the majority share in the in silico clinical trials market in 2021. The emergence of this region can be attributed to an increase in understanding of the benefits of in silico trials and reduced side effects that have been raised from human trials.
Key product releases, cost-effectiveness, and the presence of manufacturers in the country are all factors that have contributed to the growth of the in silico clinical trials market. According to the press release on May 2021, Massachusetts-based GNS Healthcare, an artificial intelligence organization that produces in silico patients that simulate therapeutic intervention on a patient-by-patient basis, announced that they are planning to develop and launch Gemini, which is an in silico Patient for Prostate Cancer. This in silico patient was created in collaboration with Tempus and is powered by clinico-genomic data, including whole-exome sequencing (tumor/normal match), RNAseq, patient treatment history, current treatments like Enzalutamide, Abiraterone, Docetaxel, Cabazitaxel, Sipuleucel-T, and Pembrolizumab, as well as related lines of treatment and mortality.
Moreover, according to the report published by the United States Food and Drug Administration on January 2022, describe that In silico clinical trials employing Computational Modeling and Simulation (CM&S), in which a device is evaluated on a cohort of virtual patients, are encouraged by the United States Food and Drug Administration and are expected to replace or augment clinical studies. However, the use of Computational Modeling and Simulation to support regulatory filings is hampered by a lack of or contradictory information on their reliability. The analyzed market is expected to grow in the North American region due to the factors mentioned above.
