Market Trends of Immunoglobulin Industry
Intravenous Segment is Expected to Hold Major Share Over the Forecast Period
Intravenous immunoglobulin (IVIG) is a therapy where a concentrated solution of immunoglobulins (antibodies) derived from pooled human blood plasma is administered directly into the bloodstream through intravenous infusion. By boosting antibody levels, IVIG helps prevent infections, improves immune function, and enhances overall immune protection. IVIG therapy provides passive immunity and supports the immune system in individuals with immunodeficiency diseases, reducing the frequency and severity of infections, improving quality of life, and potentially preventing complications associated with a weakened immune system. The major factors fueling the segment's growth are the various advantages related to IVIG therapy, the increase in the launch of IVIG drugs by prominent players, and government organisations recommending the adoption of IVIG therapy for treating immunodeficiency disorders. The expanding number of drug approvals is contributing to segment growth. For instance, in January 2022, Argenx SE revealed that Japan's Ministry of Health, Labour, and Welfare (MHLW) approved VYVGART (efgartigimod alfa) IgG1 intravenous infusion for the treatment of adult patients with generalised myasthenia gravis (gMG) who do not have a sufficient response to steroids or non-steroidal immunosuppressive therapies (ISTs).
Additionally, in February 2021, Pfizer Inc. received United States Food and Drug Administration (FDA) approval for the supplemental Biologics License Application (sBLA) for PANZYGA (Immune Globulin Intravenous [Human] - is 10% liquid preparation) to treat adult patients with a rare neurological disease of the peripheral nerves called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Panzyga is the intravenous immunoglobulin (IVIg) with two FDA-approved maintenance dosing options for CIDP, helping to meet the clinical needs of patients. Moreover, as per the article released by the NIH in December 2022, The COVID-19 Treatment Guidelines Panel (the Panel) recommended using IVIG in combination with low to moderate dose glucocorticoids in hospitalised patients for the treatment of multisystem inflammatory syndrome in children (MIS-C).
Therefore, the rising number of product launches by prominent players and government recommendations for using IVIG for treating immunodeficiency disorders are also projected to impact segment growth during the forecast period positively.
North America is Expected to Dominate the Immunoglobulin Market Over the Forecast Period
The geographical analysis of the Immunoglobulin market shows that North America holds a significant market share in the global market. The major factors driving the market growth in North America include the rising prevalence of various immunodeficiency disorders and an increasing inclination of clinicians toward immunodeficiency therapies.
The rising prevalence of HIV in the region is projected to drive the demand for immunoglobulin therapy during the forecast period. For instance, as per the article published by the United States Department of Health and Human Services (HHS) in October 2022, around 1.2 million people currently have HIV. Similarly, as per the data released by the Government of Canada in June 2023, there were about 1,472 newly diagnosed cases of HIV in Canada in 2021. Therefore, the rising prevalence of HIV in the region is projected to drive the demand for immunoglobulin therapeutics during the forecast period.
In addition, the presence of various prominent players in the region, their active participation in R&D activities, and the presence of different immunoglobulin drugs under clinical trials are projected to impact the market growth during the forecast period significantly. For instance, according to the National Clinical Trial (NCT) Registry, as of June 2023, in North America, there were around 12,327 immunoglobulin-based ongoing clinical trials across different phases of development. In addition, in January 2023, the United States FDA approved the Biologics License Application (BLA) for nirsevimab, an IgG1 antibody provided by Sanofi and AstraZeneca for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in newborns and infants. Similarly, in July 2021, the United States FDA approved Octapharma's Octogam 10% IVIg for treating adult dermatomyositis, a rare immune-mediated inflammatory disease. Thus, the abovementioned factors are expected to drive regional market growth over the forecast period.
