Market Trends of Fabry Disease Treatment Industry
Enzyme Replacement Therapy is Expected to Witness a Healthy Growth Over the Forecast Period
Patients with Fabry disease may benefit clinically from enzyme replacement therapy when treatment is started early before the development of organ damage such as chronic kidney disease or cardiac fibrosis. The two significant enzyme replacement therapies employed in treating Fabry disease include Agalsidase Beta and Agalsidase Alfa. Furthermore, upon administration, both of these mimic the actions of alpha-galactosidase A.
The studied segment is expected to grow significantly due to the higher demand for enzyme replacement therapies in treating Fabry disease and their positive outcome in patients. This is because enzyme replacement therapies such as Fabrazyme work on the primary cause of Fabry disease. For instance, Fabrazyme addresses mutations in the GLA gene, which causes the lack of alpha-galactosidase. According to an article published in October 2022 in Frontier Journal, ERT was used successfully to treat Fabry disease and entails the exogenous replacement of the GLA enzyme. Furthermore, studies demonstrated the probability of a more extended life period when enzyme replacement therapies (ERTs) are employed for FD. For instance, as per the article published in May 2022 in IntechOpen journal, enzyme replacement therapy is possible to cure FD, giving patients substantially longer life expectancies and less severe systemic symptoms than in the past. Thus, owing to the increased adoption of enzyme replacement therapies in FD, the demand for ERT is likely to rise, contributing to segment growth over the forecast period.
In addition, pharmaceutical companies are adopting strategies to market new agalsidase beta drugs to treat Fabry disease. For instance, in March 2022, JCR Pharmaceuticals Co., Ltd. entered into an agreement with Sumitomo Dainippon Pharma Co., Ltd. for marketing Agalsidase Beta BS I.V. Infusion in Japan to treat Fabry disease. Thus, owing to such a strategic agreement by the key players, the availability of ERT is expected to rise, further boosting the market growth over the study period.
Hence, owing to the rise in advantages offered by the ERT in FD and various strategic agreements by the key players, the studied segment is expected to witness significant market growth over the study period.
North America is Expected to Witness a Significant Growth Over the Forecast Period
North America is expected to witness healthy growth over the forecast period owing to the high healthcare expenditure, rise in awareness related to Fabry disease, and increase in pipeline assets and product launches of key market players in the region. For instance, in March 2022, Genzyme initiated a clinical trial to evaluate the effect of venglustat on neuropathic and abdominal pain symptoms of Fabry disease in adult participants with Fabry disease who are treatment-naïve or untreated for at least 6 months. Such clinical trials may lead to positive results leading to the introduction of new products in the market in the future and hence may contribute to the growth of the market in the future.
Furthermore, government initiatives to fund and support rare diseases across the region are expected to bolster market growth over the study period. For instance, in March 2023, the Minister of Health Canada publicized measures to support one of the first National Strategies for Drugs for Rare Diseases, with an investment of up to USD 1.5 billion over three years. Through this, the government increases access to and affordability of effective drugs for rare diseases to improve the health of patients across Canada, including children.
Therefore, owing to the rise in pipeline studies related to FD therapies and high investment from the government to support rare diseases, the studied market is expected to witness significant growth in North America over the forecast period.
