Constipation Treatment Market Size
Study Period | 2019 - 2029 |
Market Size (2024) | USD 12.38 Billion |
Market Size (2029) | USD 16.90 Billion |
CAGR (2024 - 2029) | 6.42 % |
Fastest Growing Market | North America |
Largest Market | Asia Pacific |
Market Concentration | Low |
Major Players*Disclaimer: Major Players sorted in no particular order |
Constipation Treatment Market Analysis
The Global Constipation Treatment Market size is estimated at USD 12.38 billion in 2024, and is expected to reach USD 16.90 billion by 2029, growing at a CAGR of 6.42% during the forecast period (2024-2029).
The major factor attributing to the growth of the market is the increasing number of geriatric patients and changing dietary habits, the high prevalence of irritable bowel syndrome with constipation (IBS-C), opioid-induced constipation (OIC), and chronic constipation, and the development of the latest drugs and treatment procedures.
These patients use analgesics, such as morphine, hydromorphone, and codeine, as a prescription for chronic non-cancer pain, which has severe adverse effects on the digestive system, resulting in a huge demand for constipation drugs. For instance, as per a cohort study published by the American College of Gastroenterology in November 2023, the prevalence of chronic idiopathic constipation (CIC) is common at 6.0%, while opioid-induced constipation (OIC) was 1.7% in the United States. Moreover, individuals with OIC reported a higher burden of illness concerning symptom severity and prescription constipation medication use. Thus, the huge volume of patient pools with opioid users demands efficient medication for opioid-induced constipation (OIC) ailments, which is likely to fuel the constipation treatment market during the forecast period.
The geriatric population is expected to have a significant impact on the market as people aged above 65 are more prone to chronic diseases. Geriatric people are more prone than younger adults to experience constipation-related issues. A poor diet causes this, as does a lack of sufficient fluids, a lack of exercise, the use of specific medications to treat other medical disorders, and unfavorable bowel habits, which are a few causes of this inclination. In 2022, the United Nations Department of Economic and Social Affairs (UNDESA) reported 771 million people aged 65 or over. This number is projected to increase to 994 million by 2030 and 1.6 billion by 2050. Thus, the growing geriatric population is expected to boost the target market growth over the forecast period due to the increased adoption of constipation treatments.
Furthermore, the rising initiatives from the key market players, such as the launch of innovative products, are anticipated to drive market growth. For instance, in May 2022, EA Pharma and Mochida Pharmaceutical launched MOVICOL HD, a chronic constipation treatment in Japan. MOVICAL enhances water retention in the digestive system. It also increases stool moisture, softens stool volume, physiologically activates colonic peristalsis, and encourages defecation. Therefore, the launch of products increases the availability of new products in the market, thereby contributing to market growth.
However, increasing dependence on the majority of over-the-counter (OTC) drugs and lack of awareness and reluctance among patients due to adverse effects of opioid-induced constipation (OIC) drugs are expected to hamper the target market during the forecast period.
Constipation Treatment Industry Segmentation
Peripherally Acting Mu-opioid Receptor Antagonists are Expected to Attain Significant Growth in the Constipation Treatment Market During the Forecast Period
Peripherally acting mu-opioid receptor antagonists (PAMORAs) are expected to grow significantly during the forecast period. This growth is due to the availability of various types of products launched by the key players suitable for various symptoms of opioid-induced constipation (OIC) and the rise in research activities in the segment. A few of the drugs that are readily available in the market for OIC indication are methylnaltrexone (Relistor), naldemedine (Symproic), naloxegol (Movantik), and alvimopan (Entereg).
The significance of PAMORAs in treating the OIC without disturbing the analgesic benefit of opioids is anticipated to boost segment growth. For instance, according to the study published in the Journal of Neurogastroenterology and Motility in April 2024, peripherally acting μ-opioid receptor antagonists (PAMORAs) are a category of drugs developed to mitigate opioid-induced constipation (OIC) while maintaining the analgesic benefits of opioids. The OIC is a distinct form of constipation resulting from opioids interacting with the extensive network of μ-opioid receptors in the enteric system. PAMORAs antagonize Mu receptors, maintaining gastric motility and secretion, thereby relieving constipation.
Also, the high benefits associated with PAMORA drugs in treating opioid-induced constipation are anticipated to boost the segment growth during the forecast period. For instance, according to the study published in the Journal of Pain Research in July 2023, PAMORA drugs such as methylnaltrexone are an effective and well-tolerated solution for managing OIC in cancer and non-cancer patient groups. Therefore, high tolerance levels of PAMORA drugs are anticipated to increase its adoption in OIC patients, bolstering the segment growth.
Therefore, factors such as the significance of PAMORAs in treating OIC with high tolerance and efficacy are anticipated to boost segment growth during the forecast period.
North America is Expected to Hold a Significant Market Share in the Constipation Treatment Market During the Forecast Period
North America is expected to hold a significant share of the global constipation treatment market, and it is mainly driven by the increasing prevalence of chronic constipation, the rising prevalence of irritable bowel syndrome, and growing investment in healthcare.
For instance, according to the International Foundation for Gastrointestinal Disorders 2023, in the United States, between 25 and 45 million people suffer from irritable bowel syndrome (IBS), including two-thirds of female and one-third of male patients currently. Therefore, such a huge prevalence of irritable bowel syndrome is anticipated to drive the adoption of increased stool frequency and improved stool consistency among IBS chronic constipation patients, thereby increasing the demand for effective treatment and fueling the target market growth during the forecast period.
Also, the United States holds a significant share in North America owing to factors such as the presence of a large number of market players manufacturing medications for constipation. Additionally, several market players are engaged in product launches, contributing to the region's growth. In April 2022, Ardelyx Inc. received the United States Food and Drug Administration (USFDA) for IBSRELA. This is an NHE3 inhibitor for the treatment of irritable bowel syndrome with constipation (IBS-C) in adults.
Therefore, the rising prevalence of irritable bowel syndrome and constipation, along with rising initiatives from the key market players, is anticipated to drive market growth in the region.
Constipation Treatment Industry Overview
The constipation treatment market is semi-consolidated and consists of a few major players. The factors owing to the competition include the rising initiatives from the key market players, such as launches and partnerships. Some of the companies that are operating in the market are Takeda Pharmaceutical Company Ltd, Ironwood Pharmaceuticals Inc., Bausch Health Companies Inc. (Salix Pharmaceuticals), Abbott Laboratories, AstraZeneca PLC, Sanofi SA, Bayer AG, Pfizer Inc., and Synergy Pharmaceuticals.
Constipation Treatment Market Leaders
-
Takeda Pharmaceutical Company Ltd
-
Ironwood Pharmaceuticals, Inc.
-
AstraZeneca Plc
-
Sanofi S.A.
-
Bausch Health Companies Inc. (Salix Pharmaceuticals)
*Disclaimer: Major Players sorted in no particular order
Constipation Treatment Market News
- March 2024: Sanofi Consumer Health partnered with Alliance Healthcare and Phoenix Healthcare Distribution to supply its products to pharmacies across the United Kingdom. The collaboration allows Sanofi Consumer Healthcare to enhance efficiency, develop its solutions, and increase stock availability of Allevia, Buscopan, Dulcolax, and Phenergan across the United Kingdom.
- January 2024: The consumer health division of Bayer AG launched “The Gut Gap” campaign in the United States to increase awareness about the high frequency of stress and constipation in American women. The brand commission survey was conducted to increase product outreach for MiraLax for constipation in the United States.
Global Constipation Treatment Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Increasing Geriatric Population and Changing Dietary Habits
4.2.2 High Prevalence of Irritable Bowel Syndrome with Constipation (IBS-C) and Opioid-induced Constipation (OIC) and Chronic Constipation
4.2.3 Development of Latest Drugs and Treatment Procedures
4.3 Market Restraints
4.3.1 Increasing Dependence on Majority of Over-the-Counter (OTC) Drugs
4.3.2 Lack of Awareness and Reluctance Among Patients due to Adverse Effects of Opioid-Induced Constipation (OIC) Drugs
4.4 Porter's Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
5.1 By Therapeutics
5.1.1 Laxatives
5.1.2 Chloride Channel Activators
5.1.3 Peripherally Acting Mu-Opioid Receptor Antagonists
5.1.4 GC-C Agonists
5.1.5 Other Therapeutics
5.2 By Disease Type
5.2.1 Chronic Idiopathic Constipation (CIC)
5.2.2 Irritable Bowel Syndrome with Constipation (IBS-C)
5.2.3 Opioid-induced Constipation (OIC)
5.3 By Distribution Channel
5.3.1 Hospital Pharmacies
5.3.2 Retail Pharmacies
5.3.3 Online Pharmacies
5.4 Geography
5.4.1 North America
5.4.1.1 United States
5.4.1.2 Canada
5.4.1.3 Mexico
5.4.2 Europe
5.4.2.1 Germany
5.4.2.2 United Kingdom
5.4.2.3 France
5.4.2.4 Italy
5.4.2.5 Spain
5.4.2.6 Rest of Europe
5.4.3 Asia-Pacific
5.4.3.1 China
5.4.3.2 Japan
5.4.3.3 India
5.4.3.4 Australia
5.4.3.5 South Korea
5.4.3.6 Rest of Asia-Pacific
5.4.4 Middle East and Africa
5.4.4.1 GCC
5.4.4.2 South Africa
5.4.4.3 Rest of Middle East and Africa
5.4.5 South America
5.4.5.1 Brazil
5.4.5.2 Argentina
5.4.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Takeda Pharmaceutical Company Ltd
6.1.2 Ironwood Pharmaceuticals Inc.
6.1.3 Bausch Health Companies Inc.
6.1.4 Abbott Laboratories
6.1.5 AstraZeneca PLC
6.1.6 RedHill Biopharma Ltd
6.1.7 Sanofi SA
6.1.8 Bayer AG
6.1.9 Mallinckrodt PLC
6.1.10 Synergy Pharmaceuticals Inc.
6.1.11 Johnson & Johnson (Janssen Global Services LLC)
6.1.12 ARDELYX INC.
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Constipation Treatment Industry Segmentation
As per the scope of the report, constipation is a common medical condition that affects an individual's normal life, and prolonged constipation could be a symptom of more severe diseases and disorders. It is estimated to affect every individual once in a lifetime. Constipation may be occasional, lasting for a few weeks, or chronic, lasting longer and recurrent. Therefore, it may be associated with other conditions, such as irritable bowel syndrome or opioid consumption.
The constipation treatment market is segmented by therapeutics, disease type, distribution channel, and geography. By therapeutics, the market is segmented into laxatives, chloride channel activators, peripherally acting mu-opioid receptor antagonists, GC-C agonists, and other therapeutics. By disease type, the market is segmented into chronic idiopathic constipation (CIC), irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation (OIC). By distribution channel, the market is segmented into hospitals, pharmacies, retail pharmacies, and online pharmacies. By geography, the market is segmented into North America, Europe, Asia-Pacific, Middle East and Africa, and South America. The market report also covers the estimated market sizes and trends for 17 different countries across major regions globally. The report offers the value (USD) for the above segments.
By Therapeutics | |
Laxatives | |
Chloride Channel Activators | |
Peripherally Acting Mu-Opioid Receptor Antagonists | |
GC-C Agonists | |
Other Therapeutics |
By Disease Type | |
Chronic Idiopathic Constipation (CIC) | |
Irritable Bowel Syndrome with Constipation (IBS-C) | |
Opioid-induced Constipation (OIC) |
By Distribution Channel | |
Hospital Pharmacies | |
Retail Pharmacies | |
Online Pharmacies |
Geography | ||||||||
| ||||||||
| ||||||||
| ||||||||
| ||||||||
|
Global Constipation Treatment Market Research Faqs
How big is the Global Constipation Treatment Market?
The Global Constipation Treatment Market size is expected to reach USD 12.38 billion in 2024 and grow at a CAGR of 6.42% to reach USD 16.90 billion by 2029.
What is the current Global Constipation Treatment Market size?
In 2024, the Global Constipation Treatment Market size is expected to reach USD 12.38 billion.
Who are the key players in Global Constipation Treatment Market?
Takeda Pharmaceutical Company Ltd, Ironwood Pharmaceuticals, Inc., AstraZeneca Plc, Sanofi S.A. and Bausch Health Companies Inc. (Salix Pharmaceuticals) are the major companies operating in the Global Constipation Treatment Market.
Which is the fastest growing region in Global Constipation Treatment Market?
North America is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Global Constipation Treatment Market?
In 2024, the Asia Pacific accounts for the largest market share in Global Constipation Treatment Market.
What years does this Global Constipation Treatment Market cover, and what was the market size in 2023?
In 2023, the Global Constipation Treatment Market size was estimated at USD 11.59 billion. The report covers the Global Constipation Treatment Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Global Constipation Treatment Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Global Constipation Treatment Industry Report
Statistics for the 2024 Constipation Treatment market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Constipation Treatment analysis includes a market forecast outlook to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.