Market Trends of Global Cell Based Immunotherapy Industry
Chimeric Antigen Receptor (CAR) T-Cell Therapy Is Expected To Witness Significant Growth Over The Forecast Period
Chimeric antigen receptor (CAR) T-cell therapy is a significant advancement in cancer treatment. In this therapy, the patient's T cells are genetically engineered to express an artificial receptor that binds to a tumor antigen. CAR-T cell therapy acts against CD19-coded cancer antigens to treat B-cell cancers. The rising prevalence of cancer, technological advancement in developing target-based anti-cancer therapies, and the increased adoption of cell-based therapy for therapeutic purposes are the key driving factors in the chimeric antigen receptor (CAR) T-cell therapy segment.
For instance, as per an American Cancer Society 2022 update, an estimated 10,470 children (ages 0 to 14 years) and 5,480 adolescents (ages 15-19 years) were likely to be diagnosed with cancer in the United States in 2022.
The advancements in therapy, approvals, launches, partnerships, and acquisitions by the key market players are also likely to boost segment growth. For instance, in May 2022, The European Commission (EC) approved Janssen's CAR-T therapy, Carvykti, for adults with heavily pre-treated, relapsed, and refractory multiple myeloma, marking the treatment's first approval outside of the US. Also, in March 2021 the FDA approved Abecma (idecabtagene vicleucel), the first cell-based gene therapy to treat adult multiple myeloma patients who have not responded to at least four prior rounds of therapy. It is a genetically engineered chimeric antigen receptor (CAR) T-cell therapy directed by the B-cell maturation antigen (BCMA).
North America is Expected to Witness a Growth in the Cell Based Immunotherapy Market Over The Forecast Period
North America is expected to hold a significant market share in the global cell-based immunotherapy market due to the rising prevalence of cancer, the growing awareness of cell-based therapies, the strong presence of industry players, and better healthcare infrastructure in this region. For instance, according to an American Cancer Society 2022 update, in the United States, 290,560 new cases of breast cancer, 89,010 cases of lymphoma, 62,210 cases of pancreatic cancer, 106,180 cases of colon cancer, and 44,850 cases of rectum cancer were anticipated to be diagnosed in 2022.
Furthermore, ongoing research in cancer treatment, technological advancements, product approvals, launches, partnerships, and acquisitions by the key market players also fuels the growth of the overall regional market to a large extent. For instance, in May 2022, the U.S. Food and Drug Administration (FDA) expanded its approval for a personalized cellular therapy developed at the University of Pennsylvania's Abramson Cancer Center, this time for the treatment of adults with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. The accelerated approval was granted to Novartis for the chimeric antigen receptor (CAR) T-cell therapy Kymriah (tisagenlecleucel), making it the third indication for personalized cellular therapy for cancer. It remains the only CAR-T cell therapy approved for both adult and pediatric patients.
