Cartilage Repair/Regeneration Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 1.52 Billion |
| Market Size (2029) | USD 2.89 Billion |
| CAGR (2024 - 2029) | 13.70 % |
| Fastest Growing Market | Asia-Pacific |
| Largest Market | North America |
| Market Concentration | Low |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Cartilage Repair/Regeneration Market Analysis
The Global Cartilage Repair/Regeneration Market size is estimated at USD 1.52 billion in 2024, and is expected to reach USD 2.89 billion by 2029, growing at a CAGR of 13.70% during the forecast period (2024-2029).
The key factors propelling the cartilage repair market are the rising prevalence of joints and bone disorders and the increasing geriatric population. In addition, the rising technological advancements in cartilage repair/regeneration and the growing number of injuries and accidents are further expected to propel market growth forward during the forecast period.
The surge in the burden of musculoskeletal disorders around the globe is expected to fuel the demand for cartilage replacement and repair procedures, and this, in turn, is projected to boost market growth during the study period. For instance, according to June 2024 data from the Australian Institute of Health and Welfare, osteoarthritis is one of the most common conditions in Australia, and an estimated 2.1 million (8.3%) people in Australia are living with osteoarthritis in the country.
In addition, according to the same source, osteoarthritis accounted for 2.5% of the total disease burden in Australia and 20% of the total musculoskeletal conditions in 2023. This heightened disease burden translates to the need for cartilage repair to eliminate the pain associated with the condition. Therefore, the increasing burden of musculoskeletal conditions is expected to fuel market growth during the forecast period.
Moreover, the surge in the elderly population and the increased risk of developing joint or knee-related issues are further likely to contribute to the market uptake. For instance, according to a June 2023 article published in Scientific Reports, the aging population in the United States is increasingly facing the public health challenge of osteoporotic fractures. Projections indicated that by 2025, the economic toll of these fractures is projected to exceed USD 25 billion annually, with incidences surpassing 3 million each year. In addition, the data showed that about 12.6% of United States adults aged 50 and older have osteoporosis, while 43.1% have osteopenia, a condition that can lead to osteoporosis.
Thus, the increased risk of developing osteoarthritis and joint-related issues in older adults has facilitated the development of various cell-based and non-cell-based cartilage regenerative solutions to address bone damage issues in elderly populations.
Also, the increased burden of sports-related injuries is projected to augment industry expansion during the study period. For example, based on the January 2024 update from Johns Hopkins University, approximately 30 million children engage in organized sports annually, resulting in over 3.5 million injuries per year. Therefore, such an increasing number of sports-related injuries is expected to facilitate demand for cartilage repair as sports-related injuries can damage the articular cartilage.
Moreover, technological advancements and the development of innovative treatment approaches are driving the growth of the market. For instance, in September 2022, the Drug Controller General of India (DCGI) approved Alkem Laboratories' StemOne in India. The product is indicated for the management of knee osteoarthritis, and it is the first allogeneic cell therapy product to be approved for commercial use across India.
Also, various initiatives undertaken by market participants to explore new business opportunities through strategic acquisitions and agreements are expected to support market uptake. For instance, in November 2023, Smith+Nephew signed an agreement to acquire CartiHeal, the developer of Agili-C, an innovative sports medicine solution for cartilage regeneration in the knee. Agili-C is the off-the-shelf treatment for osteochondral lesions and is designed to address a broader patient demographic, including individuals with mild to moderate osteoarthritis. Such developments undertaken by market players are anticipated to drive new business avenues, and this, in turn, is projected to support market growth over the coming years.
Therefore, abovementioned factors, like the higher burden of bone and joint disorders, the surge in the elderly population, and technological advancements in the cartilage repair arena, are expected to boost market growth during the forecast period.
However, the high costs of cartilage repair procedures and regulatory and reimbursement issues may restrain the market growth.
Cartilage Repair/Regeneration Market Trends
The Knee Application Segment is Expected to Witness Considerable Growth During the Forecast Period
The knee is the largest joint in the body, and most of the body weight goes through the knee when a person walks. Cartilage damage is a relatively common injury that often affects the knees. The knee segment is likely to grow during the forecast period due to increasing cases of knee injuries, arthritis, and the rising prevalence of osteoarthritis. The segment is further expected to be driven by the increased efforts of the market players to introduce new products for knee cartilage regeneration.
The increasing volume of research studies in the knee cartilage arena and increased efforts to evaluate the role of biomaterials in knee cartilage repair are further projected to drive segment uptake. Such studies are expected to extract new findings and are further expected to drive novel innovations in the market. For instance, in August 2024, scientists from Northwestern University developed a bioactive material that regenerated cartilage in the knee of large animal models. Such growing research efforts promise to develop new-generation cartilage regeneration products for the knees.
In addition, the surge in the adoption of new implant-based products for knee cartilage repair by healthcare facilities is further expected to augment segment growth over the coming years. For instance, in March 2024, orthopedic surgeons from UC Davis Health used the CartiHeal Agili-C Cartilage Repair Implant to relieve the knee pain of the patient. Such growing product adoption rates are expected to create new demand for cutting-edge knee cartilage products, which is projected to accelerate segment expansion over the coming years.
Moreover, the increased efforts by the market players to bolster market shares are expected to accelerate segment growth during the forecast period. For instance, in March 2023, Hy2Care initiated the next phase of its ACTIVE clinical study to enhance cartilage repair in the knee joint. The company took this step after completing the initial safety group of 10 patients. Such efforts by companies to develop new potential cartilage repair products highlight their increased initiatives to develop knee cartilage repair products.
Also, the presence of supportive regulatory legislation is further expected to fuel industry uptake over the coming years. For instance, in July 2022, Orthox Limited secured approval for the FFLEX (FibroFix Cartilage Repair Experience) study. The study received funding from the National Institute for Health and Care Research (NIHR), the Wellcome Trust, and the European Innovation Council (EIC) accelerator. The funded study aimed to evaluate the safety and performance of the Orthox FibroFix Cartilage P (FibroFix) implant, along with supplementary surgical instruments, in patients suffering from cartilage injuries in the knee joints. Such funding activities are expected to accelerate the development of new knee cartilage repair products, and this is further projected to boost segment expansion.
Therefore, the abovementioned factors, such as growing research activities, increased adoption of knee cartilage repair products, and strategic initiatives undertaken by market players, are expected to support market uptake over the coming years.
North America is Expected to Witness Healthy Growth During the Forecast Period
North America is expected to witness considerable growth in the cartilage repair market. The key driving factors of the North American cartilage repair market are the increasing incidence of bone and joint disorders, the rising geriatric population, and the increased incidence of sports injuries.
The growing burden of musculoskeletal disorders in the region is expected to drive demand for cartilage repair products to restore altered functions of bones and muscles. For instance, according to data published by the National Center For Health Statistics (NCHS), in February 2024, the age-adjusted prevalence of diagnosed arthritis in adults aged 18 and older was 18.9%, with women (21.5%) more likely to have arthritis than men (16.1%) in 2022.
Similarly, the growing incidence of spinal cord injuries and deformities further enhanced the demand for cell-based cartilage repair products in the region. For instance, according to a May 2023 report of Spinal Cord Inc., around 18,000 new spinal cord injuries occur each year in the United States, with an annual incidence rate of 54 cases per 1 million. This exponential rise in disease burden is anticipated to fuel the demand for cartilage repair products, and this is ultimately expected to accelerate market uptake over the coming years.
In addition, the high number of car crashes and car accidents are projected to have a high burden of knee damage and torn cartilage, which is expected to propel demand for knee cartilage repair products over the study period. For instance, according to the data updated by the Amaro Law Firm in March 2023, car accident results are one the key reasons for musculoskeletal injuries in the United States, and at least 7.3 million motor vehicle accidents are said to occur each year across the nation. The source also stated an estimated 19,937 car crashes every day in the United States. This high volume of road accidents is further expected to augment the demand for cartilage regeneration solutions to restore the normal functioning of muscles.
Also, the growing advancements in chondrocyte-based cartilage repair and the rising adoption of these methods in the knee and other joint-related issues are anticipated to foster market uptake over the study period. For instance, according to an article by Biomedicines in June 2024, allogeneic chondrocyte therapies are in high demand across the United States due to their effective cartilage repair capabilities. Such advances in new therapies and the adoption of chondrocyte-based cartilage repair are expected to drive regional market growth during the study period.
Hence, factors such as the growing burden of musculoskeletal disorders, increasing road accidents, and technological advancements are expected to boost market growth during the study period.
Global Cartilage Repair/Regeneration Industry Overview
The cartilage repair market is fragmented. Market players in the global cartilage repair market are expanding their product portfolios through acquisitions, mergers, and partnerships. The major players are Zimmer Biomet, Stryker Corporation, Arthrex Inc., Smith+Nephew PLC, and Vericel Corporation.
Global Cartilage Repair/Regeneration Market Leaders
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Zimmer Biomet
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Stryker Corporation
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Arthrex, Inc.
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Smith & Nephew plc
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Vericel Corporation
*Disclaimer: Major Players sorted in no particular order
Global Cartilage Repair/Regeneration Market News
- January 2024: Smith+Nephew acquired CartiHeal, the developer of Agili-C, an innovative sports medicine technology for cartilage regeneration in the knee.
- April 2024: Hyalex Orthopaedics completed the successful implantation of HYALEX knee implants in patients during its first-in-human clinical trials of the novel HYALEX knee cartilage system. The company conducted two prospective, multi-center, single-arm studies in the United States and Europe. Patient enrollment and treatment have already been completed at the study sites.
Global Cartilage Repair/Regeneration Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Rising Prevalence of the Joints and Bones Disorders Across the Globe and Increasing Geriatric Population
4.2.2 Technological Advancements in Cartilage Repair/Regeneration
4.2.3 Increasing Number of Sport Injuries and Accidents
4.3 Market Restraints
4.3.1 High Costs of Cartilage Repair Procedures
4.3.2 Regulatory and Reimbursement Issues
4.4 Porter's Five Force Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
5.1 By Types of Cartilage
5.1.1 Fibrocartilage
5.1.2 Hyaline Cartilage
5.1.3 Other Types of Cartilage
5.2 By Treatment Modality
5.2.1 Cell-based
5.2.2 Non-cell-based
5.3 By Treatment Type
5.3.1 Palliative
5.3.2 Intrinsic Repair Stimulus
5.4 By Application
5.4.1 Knee
5.4.2 Spine
5.4.3 Ankle
5.4.4 Hip
5.4.5 Other Applications
5.5 Geography
5.5.1 North America
5.5.1.1 United States
5.5.1.2 Canada
5.5.1.3 Mexico
5.5.2 Europe
5.5.2.1 Germany
5.5.2.2 United Kingdom
5.5.2.3 France
5.5.2.4 Italy
5.5.2.5 Spain
5.5.2.6 Rest of Europe
5.5.3 Asia-Pacific
5.5.3.1 China
5.5.3.2 Japan
5.5.3.3 India
5.5.3.4 Australia
5.5.3.5 South Korea
5.5.3.6 Rest of Asia-Pacific
5.5.4 Middle East and Africa
5.5.4.1 GCC
5.5.4.2 South Africa
5.5.4.3 Rest of Middle East and Africa
5.5.5 South America
5.5.5.1 Brazil
5.5.5.2 Argentina
5.5.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Anika Therapeutics Inc.
6.1.2 Arthrex Inc.
6.1.3 B. Braun SE
6.1.4 CYFUSE BIOMEDICAL K.K.
6.1.5 Johnson & Johnson Services Inc.
6.1.6 Geistlich Pharma AG
6.1.7 Smith+Nephew
6.1.8 Stryker
6.1.9 Vericel Corporation
6.1.10 Zimmer Biomet
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Global Cartilage Repair/Regeneration Industry Segmentation
As per the scope of the report, cartilage is a white polished material that helps cushion and cover the region where the bones meet joints. It acts as both a lubricating surface and a shock absorber. Cartilage damage can be a hole or crater on the smooth, superficial surface of the joint. The joint may become inflexible, swollen, and tender if left untreated. It can even develop to a stage that requires a total joint replacement with metal and plastic components. Cartilage repair or regeneration is a process that aims to restore injured cartilage by stimulating the body's cells to regrow or replace lost cartilage.
The cartilage repair market is segmented by types of cartilage, treatment modality, treatment type, application, and geography. By type of cartilage, the market is segmented as fibrocartilage, hyaline cartilage, and others. By treatment modality, the market is bifurcated into cell-based and non-cell-based. By treatment type, the market is segmented as a palliative and intrinsic repair stimulus. By application, the market is segmented into knee, spine, ankle, hip, and other applications. By geography, the market is segmented into North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. The report also covers market sizes and forecasts for the cartilage repair market in major countries across different regions. For each segment, the market size and forecasts are provided in terms of value (USD).
| By Types of Cartilage | |
| Fibrocartilage | |
| Hyaline Cartilage | |
| Other Types of Cartilage |
| By Treatment Modality | |
| Cell-based | |
| Non-cell-based |
| By Treatment Type | |
| Palliative | |
| Intrinsic Repair Stimulus |
| By Application | |
| Knee | |
| Spine | |
| Ankle | |
| Hip | |
| Other Applications |
| Geography | ||||||||
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Global Cartilage Repair/Regeneration Market Research Faqs
How big is the Global Cartilage Repair/Regeneration Market?
The Global Cartilage Repair/Regeneration Market size is expected to reach USD 1.52 billion in 2024 and grow at a CAGR of 13.70% to reach USD 2.89 billion by 2029.
What is the current Global Cartilage Repair/Regeneration Market size?
In 2024, the Global Cartilage Repair/Regeneration Market size is expected to reach USD 1.52 billion.
Who are the key players in Global Cartilage Repair/Regeneration Market?
Zimmer Biomet, Stryker Corporation, Arthrex, Inc., Smith & Nephew plc and Vericel Corporation are the major companies operating in the Global Cartilage Repair/Regeneration Market.
Which is the fastest growing region in Global Cartilage Repair/Regeneration Market?
Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Global Cartilage Repair/Regeneration Market?
In 2024, the North America accounts for the largest market share in Global Cartilage Repair/Regeneration Market.
What years does this Global Cartilage Repair/Regeneration Market cover, and what was the market size in 2023?
In 2023, the Global Cartilage Repair/Regeneration Market size was estimated at USD 1.31 billion. The report covers the Global Cartilage Repair/Regeneration Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Global Cartilage Repair/Regeneration Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
Global Cartilage Repair/Regeneration Industry Report
Statistics for the 2024 Cartilage Repair market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Cartilage Repair analysis includes a market forecast outlook 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.
