Antibody Drug Conjugates Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 12.05 Billion |
| Market Size (2029) | USD 44.05 Billion |
| CAGR (2024 - 2029) | 29.57 % |
| Fastest Growing Market | Asia-Pacific |
| Largest Market | North America |
| Market Concentration | Low |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Antibody Drug Conjugates Market Analysis
The Antibody Drug Conjugates Market size is estimated at USD 12.05 billion in 2024, and is expected to reach USD 44.05 billion by 2029, growing at a CAGR of 29.57% during the forecast period (2024-2029).
The COVID-19 pandemic had a notable impact on the Antibody Drug market since many cancer consultations and treatments were postponed or canceled due to the lockdown restrictions. For instance, according to the National Health Service (NHS) of the United Kingdom, in 2023, there was a shortfall in cancer treatments during the pandemic, driven by a sharp drop in urgent referrals as people needed to stay at home due to the lockdown restrictions, which significantly reduced the demand for overall cancer therapies including Antibody Drug Conjugate (ADC).
Moreover, according to the Annual Report 2022 of Seagen Inc., a leading manufacturer among Antibody Drug Conjugate companies, the COVID-19 pandemic had adverse impacts on the ADC companies' business, including commercialization efforts, supply chain, regulatory activities, clinical development activities, and others. Thus, the COVID-19 pandemic significantly impacted the business operations of ADC vendors, thereby impacting the sale of Antibody Drug Conjugates. However, the increasing approvals and launches of Antibody Drug Conjugates in the post-pandemic period are expected to drive the ADC market growth over the coming years.
The major factors responsible for the growth of the ADC market include the growing prevalence of cancer, the increasing geriatric population, and increasing R&D activities for the development of novel therapeutics. Antibody Drug Conjugates, or Conjugated Monoclonal Antibodies, offer one of the most effective treatments for cancer patients. They can exploit the specificity of Monoclonal Antibodies toward targeted antigens for the release of potential Cytotoxic Payload, with increased activity and decreased toxicity compared to chemotherapies.
The rising incidence of cancer in various countries increases the usage of ADC for treatment. For instance, according to the May 2022 update by the Canadian Cancer Society, 28,600 Canadian women were diagnosed with breast cancer in 2022, representing 25% of all new cancer cases in women in 2022. Also, on average, 78 Canadian women were expected to be diagnosed with breast cancer daily in 2022. Thus, owing to the high prevalence and increasing probability of acquiring breast cancer among females, the demand for Antibody Drug Conjugates, a form of Targeted Cancer Therapeutics, is likely to rise, fueling the market growth over the forecast period.
The increasing investments in the ADC market are expected to boost the Antibody Drug Conjugate pipeline and expand its applications, highlighting the Antibody Drug Conjugate market potential, which may positively impact the market's growth. For instance, in June 2022, Spirea Limited secured funding of GBP 2.4 (USD 3.06) million with investments from high-profile investors from the United Kingdom and the United States. The company uses these funds to initiate its pipeline of superior and differentiated ADCs in the treatment of solid tumors, thereby contributing to the growth of the market.
However, the stringent government regulations and high Antibody Drug Conjugate cost are expected to restrain the market's growth over the forecast period.
Antibody Drug Conjugates Market Trends
Breast Cancer Segment accounted for the Largest Share of the Market
- The breast cancer segment is expected to witness significant growth over the forecast period due to the rising incidences of breast cancer worldwide. In addition, the growing product approvals and launches and ongoing clinical trials for breast cancers using Antibody Drug Conjugates contribute to ADC market growth over the forecast period.
- The success of Antibody Drug Conjugate in breast cancer has led to many new clinical studies in the field of Precision Oncology that are likely to boost the market's growth. For instance, the study published in the Journal of Cancer Research in February 2022 reported the most promising new ADC, which appears to be the TROP2-directed datopotamab deruxtecan, has shown encouraging early-phase activity in advanced relapsed/refractory HER2-negative breast cancer.
- Similarly, in March 2023, Ambrx Biopharma Inc. was informed by its partner, NovoCodex Biopharmaceuticals, Inc., that an interim analysis for ACE-Breast-02, a randomized Phase 3 breast cancer clinical trial investigating Ambrx's ARX788, an anti-HER2 Antibody Drug Conjugate (ADC), has met its pre-specified interim primary efficacy endpoint with statistical significance, demonstrating a greater progression-free survival (PFS) benefit compared to the active control. Thus, such clinical trials are leading to the development of better Targeted Cancer Therapeutics for the treatment of breast cancer.
- The new approvals and launches of ADC for breast cancers increase the demand for this drug, which likely boosts the segment growth over the study period. For instance, in February 2023, Gilead Sciences, Inc. received approval from the United States Food and Drug Administration (FDA) for Trodelvy (sacituzumab govitecan-hziy) for the treatment of adult patients with unresectable locally advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative (IHC 0, IHC 1+ or IHC 2+/ISH-) breast cancer who have received endocrine-based therapy and at least two additional systemic therapies in the metastatic setting.
- Thus, the increasing R&D for breast cancer treatment and product approvals are anticipated to increase the use of Antibody Drug Conjugates in the treatment of breast cancer, boosting the Antibody Drug market and thus enhancing the segment's growth over the forecast period.
North America is Expected to Witness Significant Growth Over the Forecast Period
- North America is expected to witness significant growth over the forecast period due to rising cancer cases and technological developments. The region is observing significant growth due to technological advancements, the local presence of key players, and strategic initiatives by leaders in countries such as the United States and Canada. In April 2021, Pfizer acquired Amplyx Pharmaceuticals Inc. to develop Antibody Drug Conjugates and several other therapies for cancer.
- North American countries are marked by high cancer cases. The increasing number of cancer cases is driving the growth of the market in the region. For instance, according to the 2021 and 2023 statistics published by the American Cancer Society (ACS), the incidence of cancer cases is estimated to increase from 1.91 million in 2021 to 1.96 million in 2023, an increase of more than 60 thousand cases in just two years, demonstrating a rapid increase in the incidence of cancer cases in the country. The chance of an increase in the incidence of cancer is likely to be high in the country, thus raising the demand for advanced oncology treatment, which ultimately boosts the Global ADC market growth.
- Antibody Drug Conjugate companies are expanding their portfolios with partnerships and new product approvals, which are expected to have significant impact on the market growth. For instance, in February 2023, Corbus Pharmaceuticals Holdings, Inc. entered into an exclusive licensing agreement with CSPC Megalith Biopharmaceutical Co., Ltd, a subsidiary of CSPC Pharmaceutical Group Limited, for the development and commercialization of CRB-701 (SYS6002). The agreement covers exclusive commercialization rights to CRB-701 in the United States and Canada. In addition, in February 2022, Adcentrx Therapeutics and AvantGen entered a three-year, multi-target partnership for the discovery of antibodies to be developed into novel Antibody Drug Conjugate therapeutic candidates.
- Thus, owing to the growing number of cancer cases and strategic partnerships among the key players, along with regulatory approvals, the North American Antibody Drug Conjugates market is expected to grow significantly during the forecast period.
Antibody Drug Conjugates Industry Overview
The Antibody Drug Conjugates market is slightly fragmented in nature and competitive due to the presence of several companies across the globe. The competitive landscape includes an analysis of international, local, and top ADC companies that hold major market shares, including Seagen Inc., ImmunoGen Inc., Pfizer Inc., F. Hoffmann-La Roche Ltd, AbbVie Inc., AstraZeneca PLC, Gilead Sciences Inc., and others.
Antibody Drug Conjugates Market Leaders
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Seagen Inc.
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F Hoffmann-La Roche Ltd
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Pfizer Inc
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AstraZeneca
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Gilead Sciences, Inc
*Disclaimer: Major Players sorted in no particular order
Antibody Drug Conjugates Market News
- July 2023: Gilead Sciences, Inc. received approval from the European Commission (EC) for Trodelvy (sacituzumab govitecan) as a monotherapy for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-negative breast cancer who have received endocrine-based therapy, and at least two additional systemic therapies in the advanced setting.
- July 2023: BeiGene and DualityBio entered a partnership agreement for BeiGene to acquire an exclusive option for a global clinical and commercial license to an investigational, preclinical ADC therapy for patients with select solid tumors.
Antibody Drug Conjugates Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Increasing Incidences of Cancer
4.2.2 Growing Geriatic Population
4.2.3 Increasing R&D Activities for the Development of Novel Therapeutics
4.3 Market Restraints
4.3.1 Stringent Government Regulations
4.3.2 High Manufacturing Costs of Antibody Drug Conjugates
4.4 Industry Attractiveness - Porter's Five Forces Analysis
4.4.1 Bargaining Power of Buyers/Consumers
4.4.2 Bargaining Power of Suppliers
4.4.3 Threat of New Entrants
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value - USD)
5.1 By Product Type
5.1.1 Adcetris
5.1.2 Kadcyla
5.1.3 Other Product Types
5.2 By Application
5.2.1 Blood Cancer
5.2.2 Breast Cancer
5.2.3 Ovary Cancer
5.2.4 Lung Cancer
5.2.5 Skin Cancer
5.2.6 Brain Tumor
5.2.7 Other Applications
5.3 By Technology
5.3.1 Clevable Linker
5.3.2 Non-cleavable Linker
5.4 By Target Type
5.4.1 CD30 Antibodies
5.4.2 HER2 Antibodies
5.4.3 Other Target Types
5.5 By End User
5.5.1 Hospitals and Speciality Cancer Centers
5.5.2 Biotechnology and Pharmaceutical Companies
5.5.3 Other End Users
5.6 Geography
5.6.1 North America
5.6.1.1 United States
5.6.1.2 Canada
5.6.1.3 Mexico
5.6.2 Europe
5.6.2.1 Germany
5.6.2.2 United Kingdom
5.6.2.3 France
5.6.2.4 Italy
5.6.2.5 Spain
5.6.2.6 Rest of Europe
5.6.3 Asia-Pacific
5.6.3.1 China
5.6.3.2 Japan
5.6.3.3 India
5.6.3.4 Australia
5.6.3.5 South Korea
5.6.3.6 Rest of Asia-Pacific
5.6.4 Middle East and Africa
5.6.4.1 GCC
5.6.4.2 South Africa
5.6.4.3 Rest of Middle East and Africa
5.6.5 South America
5.6.5.1 Brazil
5.6.5.2 Argentina
5.6.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 Seagen Inc.
6.1.2 ImmunoGen Inc.
6.1.3 Mersana Therapeutics Inc.
6.1.4 Pfizer Inc.
6.1.5 F. Hoffmann-La Roche Ltd
6.1.6 Sorrento Therapeutics Inc.
6.1.7 Oxford BioTherapeutics Ltd
6.1.8 AbbVie Inc.
6.1.9 Takeda Pharmaceutical Company Ltd
6.1.10 AstraZeneca PLC
6.1.11 ADC Therapeutics SA
6.1.12 Gilead Sciences Inc.
6.1.13 GSK plc.
6.1.14 Daiichi Sankyo Company, Limited
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
Antibody Drug Conjugates Industry Segmentation
Antibody drug conjugates are a class of biopharmaceuticals designed for the treatment of cancer, comprising an antibody that specifically targets a tumor antigen and a cytotoxic compound connected via a chemical linker. These are intended to allow the specific targeting of the cytotoxic compound to kill cancer cells while having a limited effect on healthy tissue.
The antibody drug conjugates market is segmented by product type (adcetris, kadcyla, and other product types), application (blood cancer, breast cancer, ovary cancer, lung cancer, skin cancer, brain tumor, and other applications), technology (cleavable linker and non-cleavable linker), target type (CD30 antibodies, HER2 antibodies, and other target types), end user (hospitals and specialty cancer centers, biotechnology and pharmaceutical companies, and other end users), and geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report also covers the estimated antibody drug conjugates market sizes and trends for 17 countries across major regions globally.
The report offers the value in USD for the above segments.
| By Product Type | |
| Adcetris | |
| Kadcyla | |
| Other Product Types |
| By Application | |
| Blood Cancer | |
| Breast Cancer | |
| Ovary Cancer | |
| Lung Cancer | |
| Skin Cancer | |
| Brain Tumor | |
| Other Applications |
| By Technology | |
| Clevable Linker | |
| Non-cleavable Linker |
| By Target Type | |
| CD30 Antibodies | |
| HER2 Antibodies | |
| Other Target Types |
| By End User | |
| Hospitals and Speciality Cancer Centers | |
| Biotechnology and Pharmaceutical Companies | |
| Other End Users |
| Geography | ||||||||
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Antibody Drug Conjugates Market Research Faqs
How big is the Antibody-drug Conjugates Market?
The Antibody-drug Conjugates Market size is expected to reach USD 12.05 billion in 2024 and grow at a CAGR of 29.57% to reach USD 44.05 billion by 2029.
What is the current Antibody-drug Conjugates Market size?
In 2024, the Antibody-drug Conjugates Market size is expected to reach USD 12.05 billion.
Who are the key players in Antibody-drug Conjugates Market?
Seagen Inc., F Hoffmann-La Roche Ltd, Pfizer Inc, AstraZeneca and Gilead Sciences, Inc are the major companies operating in the Antibody-drug Conjugates Market.
Which is the fastest growing region in Antibody-drug Conjugates Market?
Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Antibody-drug Conjugates Market?
In 2024, the North America accounts for the largest market share in Antibody-drug Conjugates Market.
What years does this Antibody-drug Conjugates Market cover, and what was the market size in 2023?
In 2023, the Antibody-drug Conjugates Market size was estimated at USD 8.49 billion. The report covers the Antibody-drug Conjugates Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Antibody-drug Conjugates Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
What are the emerging technologies impacting the Antibody Drug Conjugates Market?
The emerging technologies impacting the Antibody Drug Conjugates Market are a) AI-powered drug design b) Next-generation linker technologies c) Targeted delivery systems
Antibody Drug Conjugates Industry Report
The global antibody drug conjugates (ADCs) market is experiencing significant growth, driven by the rising prevalence of cancer and the increasing demand for more effective, targeted treatments. This market encompasses a variety of cancer types, including breast and blood cancer, and is benefiting from a surge in research and development for innovative ADCs. The integration of ADCs with other anticancer therapies, such as immunotherapy and chemotherapy, is creating new opportunities for market growth.
Advances in technology are enhancing the efficacy of ADCs while addressing concerns related to toxicity. Despite the complexities involved in ADC development and the potential side effects, increased investments and collaborations are having a positive impact on the market. The ADC sector, with its diverse product range and ongoing technological improvements, is well-positioned to meet oncology's unmet medical needs.
The market size and market share of ADCs are crucial metrics for understanding the industry's landscape. Annual reports and market growth analyses provide insights into the market forecast and market analysis. The global market for ADCs is characterized by a comprehensive market overview and market research, which are essential for understanding market trends and market value.
Industry analysis and industry information are vital for gaining a deeper understanding of the ADC market. Industry outlook and industry reports offer detailed insights into industry research and industry sales. Industry size and industry statistics provide valuable data for assessing industry trends and market data.
The market forecast for ADCs indicates a positive trajectory, with market growth driven by various factors. Market leaders in the ADC industry are setting the pace for market outlook and market predictions. A thorough market review and market segmentation help in understanding the market value and identifying key areas for growth.
Report examples and report PDFs are useful resources for research companies and other stakeholders interested in the ADC market. The growth rate of ADCs is a critical factor for industry analysis, and industry information is essential for making informed decisions. The industry outlook and industry reports provide a comprehensive view of the market, while industry research and industry sales data offer insights into market dynamics.
In summary, the ADC market is poised for substantial growth, supported by technological advancements, increased investments, and a focus on meeting the unmet medical needs in oncology. The market data, market forecast, market growth, and market trends all point towards a promising future for ADCs, making it a key area of interest for industry stakeholders.
Antibody Drug Conjugates Market Report Snapshots
