3D Cell Culture Market Size
| Study Period | 2019 - 2029 |
| Market Size (2024) | USD 2.01 Billion |
| Market Size (2029) | USD 4.09 Billion |
| CAGR (2024 - 2029) | 15.26 % |
| Fastest Growing Market | Asia-Pacific |
| Largest Market | North America |
| Market Concentration | Medium |
Major Players
*Disclaimer: Major Players sorted in no particular order |
3D Cell Culture Market Analysis
The Global 3D Cell Culture Market size is estimated at USD 2.01 billion in 2024, and is expected to reach USD 4.09 billion by 2029, at a CAGR of 15.26% during the forecast period (2024-2029).
The 3D cell culture market is witnessing stable growth due to factors like the use of 3D cell culture models as alternative tools for in vivo testing, the development of large-scale automated cell culture systems, and the rising need for organ transplantation. The 3D cell culture and co-culture models have huge benefits since they not only enable drug safety and efficacy assessment in a more in vivo–like context than traditional 2D cell cultures, but they can also eliminate the species differences that pose limitations in the interpretation of the preclinical outcomes by allowing drug testing directly in human systems.
Additionally, with the increase in demand for organ transplantation, there is likely to be a demand for 3D cell cultures as there is a need to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. According to the United States Health Resources and Services Administration, in March 2024, 103,223 patients were on the national organ transplant waiting list for the year 2023. Data from the website also states that more than 46,000 transplants were performed in 2023 in the United States. Thus, the increase in organ transplants is increasing the demand for research models where 3D cell cultures are used. This is expected to boost the market's growth.
The 3D cell culture system is crucial for developing organoids and functional tissue constructs, which are vital for transplantation and drug response analysis. Additionally, companies are introducing products that significantly enhance tissue culture and tissue engineering applications are expected to increase demand for the 3D cell culture products is anticipated to boost the market over the forecast period. For instance, in June 2023, 3D BioFibR launched two new collagen fiber products for 3D bioprinting: the CollaFibR 3D scaffold and μCollaFibR, both designed to improve 3D cell culture methods.
Furthermore, product launches by the market players are expected to propel the growth of the market. For instance, in August 2024, CytoNest Inc., a startup from the University of Georgia, launched its inaugural commercial product: the CytoSurge 3D fiber scaffold. This innovative fiber scaffold enhances cell manufacturing and tissue engineering. With its versatile applications, the CytoSurge 3D fiber scaffold is poised to make significant contributions to cell research, biopharmaceuticals, cell therapeutics, and the development of cultured meat and seafood. Similarly, in October 2024, CD Bioparticles unveiled its latest innovation: a 3D Cell Culture Substrate tailored for tissue engineering scaffold research. This biocompatible, three-dimensional matrix empowers researchers to craft precise models, enhancing studies on cell behavior, drug screening, and tissue engineering.
Due to the increasing rates of organ transplantation and strategic initiatives by market players, the cell culture market is projected to experience substantial growth during the forecast period. However, a shortage of skilled and experienced professionals may impede this market expansion.
3D Cell Culture Market Trends
The Microchips Segment under Product is Expected to see Significant Growth Rate Over the Forecast Period
Microchips, often referred to as "organs-on-a-chip" or "microsystems," integrate microfluidic technologies with cultured cells in microfabricated 3D devices, utilizing various techniques from the microchip industry. Increasing R&D activities, technological advancements, and product launches are driving the segment's growth.
Technological advancements in microchips are boosting their adoption in R&D, propelling segment growth. For instance, in June 2024, Dynamic42, a leading organ-on-chip specialist from Jena, introduced the "DynamicOrgan System". This platform distinguishes itself by eliminating capital expenditure (capex) and adhering to industry standards, enabling users to utilize their existing equipment. The Developer Kit, a core component, includes biochips and consumables for organ model setups, ensuring seamless integration with current pump systems. For newcomers to organ-on-chip technology, Dynamic42 offers compatible pumps with the DynamicOrgan System. This system, designed for any standard cell culture environment, enables researchers to create realistic human organ models and explore various bioprocess studies. Thus, such technological advancements in microchips are likely to boost adoption and contribute to market growth during the forecast period.
Microchips boast a primary advantage: low-cost manufacturing. They facilitate testing across a broad spectrum of medicine dosages, a benefit poised to drive demand and significantly accelerate scientific research. Recently, organ chip technology has seen innovative applications in drug discovery. For instance, in May 2022, AIM Biotech's scientists introduced the idenTx organ-on-a-chip (OOAC) platform, emphasizing a user-friendly system for OOAC-based tissue culture assays. These platforms allow human cell co-culture, accurately replicating human tissues and disease states, surpassing traditional 2D tissue culture capabilities.
Moreover, strategic moves by industry players are set to bolster segment growth in the coming years. For example, in November 2024, InSphero teamed up with Chayon, a leading laboratory supplies firm in Seoul, South Korea. This partnership signifies InSphero's foray into the 3D Cell Culture market, allowing them to showcase their advanced Akura Plate Technology and Akura Organ-on-Chip Platforms to a broader audience.
Consequently, given the highlighted advantages and ongoing research in microchips, the market is poised for growth, especially in 3D cell culture technologies.
North America Holds Significant Share in the Market and Expected to Grow in Forecast Period
North America leads the global 3D cell culture market, with the United States as its primary contributor. Over recent years, the United States has heavily invested in research and development for 3D cell cultures, driving technological advancements. Many United States entities rank among the top patent applicants in the 3D cell culture arena, often developing their technologies in both the United States and Canada.
As the demand for organ transplants rises in the region, so does the need to replicate complex human physiological and pathological responses in vitro. In 2023, Canada performed 3,428 organ transplants, with 83% from deceased and 17% from living donors, as reported by the Canadian Institute for Health Information. These dynamics are poised to bolster the market in North America during the forecast period.
Industry collaborations and product launches are pivotal in driving the 3D cell culture market. Such partnerships enable companies to pool resources, enhance technological capabilities, and penetrate new markets, expediting innovation and adoption. For example, in April 2024, Sartorius teamed up with United States-based startup TheWell Bioscience to develop hydrogels and bioinks for advanced 3D cell models, streamlining drug discovery. In another instance, Curi Bio unveiled two platforms, Nautilus and Stringray, in September 2023, to support researchers in 2D and 3D cell culture studies, especially in electrophysiology.
Given the rising demand for organ transplants and the surge in product launches and strategic collaborations, the North American market is set for growth in the coming years.
3D Cell Culture Industry Overview
The 3D cell culture market is semi-consolidated and consists of several major players. In terms of market share, few of the major players currently dominate the market. The presence of major market players, such as Corning Incorporated, Lonza AG, Merck KGaA, and Thermo Fisher Scientific, and among others.
3D Cell Culture Market Leaders
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Corning Incorporated
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Lonza AG
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Thermo Fisher Scientific
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Merck KGaA
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MIMETAS BV
*Disclaimer: Major Players sorted in no particular order
3D Cell Culture Market News
- February 2023: CN Bio launched its commercial product, PhysioMimix, a high-throughput system designed for single-organ studies. This system facilitates the early adoption of human predictive liver models in drug discovery workflows. Utilizing 3D cell culture systems like PhysioMimix enables researchers to better simulate organ and tissue behavior, resulting in more pertinent and dependable preclinical research outcomes.
- February 2023: Corning Life Sciences is set to introduce its cutting-edge 3D culture tools, alongside a novel Elplasia plate designed with an open-well format to facilitate easier manipulation of spheroids and organoids.
Global 3D Cell Culture Market Report - Table of Contents
1. INTRODUCTION
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Use of 3D Cell Culture Models as Alternative Tools for In Vivo Testing
4.2.2 Development of Automated Large-scale Cell Culture Systems
4.2.3 Rising Need for Organ Transplantation
4.3 Market Restraints
4.3.1 Lack of Experienced and Skilled Professionals
4.3.2 Budget Restriction for Small- and Medium-sized Laboratories
4.4 Porter's Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION (Market Size by Value – USD)
5.1 By Product
5.1.1 Scaffold-based 3D Cell Cultures
5.1.1.1 Micropatterned Surface Microplates
5.1.1.2 Hydrogels
5.1.1.3 Other Products
5.1.2 Scaffold-free 3D Cell Cultures
5.1.2.1 Hanging drop microplates
5.1.2.2 Microfluidic 3D cell culture
5.1.2.3 Other Products
5.1.3 Microchips
5.1.4 3D Bioreactors
5.2 By Application
5.2.1 Drug Discovery
5.2.2 Tissue Engineering
5.2.3 Clinical Applications
5.2.4 Other Applications
5.3 By End User
5.3.1 Research Laboratories and Institutes
5.3.2 Biotechnology and Pharmaceutical Companies
5.3.3 Other End Users
5.4 Geography
5.4.1 North America
5.4.1.1 United States
5.4.1.2 Canada
5.4.1.3 Mexico
5.4.2 Europe
5.4.2.1 Germany
5.4.2.2 United Kingdom
5.4.2.3 France
5.4.2.4 Italy
5.4.2.5 Spain
5.4.2.6 Rest of Europe
5.4.3 Asia-Pacific
5.4.3.1 China
5.4.3.2 Japan
5.4.3.3 India
5.4.3.4 Australia
5.4.3.5 South Korea
5.4.3.6 Rest of Asia-Pacific
5.4.4 Middle East and Africa
5.4.4.1 GCC
5.4.4.2 South Africa
5.4.4.3 Rest of Middle East and Africa
5.4.5 South America
5.4.5.1 Brazil
5.4.5.2 Argentina
5.4.5.3 Rest of South America
6. COMPETITIVE LANDSCAPE
6.1 Company Profiles
6.1.1 BiomimX SRL
6.1.2 CN Bio Innovations
6.1.3 Corning Incorporated
6.1.4 Hurel Corporation
6.1.5 InSphero AG
6.1.6 Lonza AG
6.1.7 Merck KGaA
6.1.8 MIMETAS BV
6.1.9 Nortis Inc.
6.1.10 Thermo Fisher Scientific
6.1.11 Sartorius AG
6.1.12 Promocell GmbH
- *List Not Exhaustive
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
3D Cell Culture Industry Segmentation
As per the scope of the report, 3-dimensional (3D) cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. The 3D cell culture market is segmented by product, application, end-user, and geography. By product, the market is segmented as scaffold-based 3D cell cultures, scaffold-free 3D cell cultures, microchips, and 3D Bioreactors. By application, the market is segmented as drug discovery, tissue engineering, clinical applications, and other applications. By end user, the market is segmented as research laboratories and institutes, biotechnology and pharmaceutical companies and other end users. By geography, the market is segmented as North America, Europe, Asia-Pacific, Middle-East and Africa, and South America. The market report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD) for the above segments.
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| Microchips | |||||
| 3D Bioreactors |
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| Drug Discovery | |
| Tissue Engineering | |
| Clinical Applications | |
| Other Applications |
| By End User | |
| Research Laboratories and Institutes | |
| Biotechnology and Pharmaceutical Companies | |
| Other End Users |
| Geography | ||||||||
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Global 3D Cell Culture Market Research Faqs
How big is the Global 3D Cell Culture Market?
The Global 3D Cell Culture Market size is expected to reach USD 2.01 billion in 2024 and grow at a CAGR of 15.26% to reach USD 4.09 billion by 2029.
What is the current Global 3D Cell Culture Market size?
In 2024, the Global 3D Cell Culture Market size is expected to reach USD 2.01 billion.
Who are the key players in Global 3D Cell Culture Market?
Corning Incorporated, Lonza AG, Thermo Fisher Scientific, Merck KGaA and MIMETAS BV are the major companies operating in the Global 3D Cell Culture Market.
Which is the fastest growing region in Global 3D Cell Culture Market?
Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).
Which region has the biggest share in Global 3D Cell Culture Market?
In 2024, the North America accounts for the largest market share in Global 3D Cell Culture Market.
What years does this Global 3D Cell Culture Market cover, and what was the market size in 2023?
In 2023, the Global 3D Cell Culture Market size was estimated at USD 1.70 billion. The report covers the Global 3D Cell Culture Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Global 3D Cell Culture Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.
What are the key challenges hindering wider adoption of 3D Cell Cultures?
The key challenges hindering wider adoption of 3D Cell Cultures are a) High costs b) Complex protocols c) Limited standardization across platforms
Global 3D Cell Culture Industry Report
The global 3D cell culture market is poised for substantial growth, driven by the shift towards alternatives to animal testing and a surge in demand for accurate biological models for research and drug development. This growth is supported by various end-users like biotechnology, pharmaceutical companies, and academic institutions. Advancements in tissue engineering and the push for personalized medicine are boosting the adoption of 3D cell cultures. Key market segments like scaffold-based cell cultures leveraging hydrogels and polymeric scaffolds are crucial due to their ability to mimic the extracellular matrix closely. Emerging technologies such as microfluidics-based and scaffold-free systems are gaining traction, enhanced by their support for high-throughput screening. Geographically, North America leads due to robust infrastructure and significant investment, while Asia-Pacific shows rapid growth due to increasing health concerns and biomedical advancements. Market leaders are focusing on strategic partnerships and new product developments to expand their 3D cell culture offerings. Get insights into these trends with a free report PDF download from Mordor Intelligence™ Industry Reports.
Global 3D Cell Culture Market Report Snapshots
