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Markt-Trends von Globale Cephalosporin-Medikamente Industrie
Für das Segment der fünften Generation wird im Prognosezeitraum ein gesundes Wachstum erwartet
Es wurde festgestellt, dass die Cephalosporine der fünften Generation im Labor speziell für die Bekämpfung resistenter Bakterienstämme entwickelt wurden. Zu den Cephalosporinen der fünften Generation gehören Ceftobiprol, Ceftarolin und Ceftolozan. Diese Wirkstoffe werden manchmal als fortgeschrittene Generation und nicht als Cephalosporine der fünften Generation bezeichnet. Cephalosporine haben ähnliche Nebenwirkungen wie Penicillin sowie Arzneimittelallergien und Überempfindlichkeit. Cephalosporine wurden im Allgemeinen mit geringer Hepatotoxizität und seltenen Fällen arzneimittelbedingter Leberschäden in Verbindung gebracht. Ceftobiprol hat sich als wirksam gegen Methicillin-resistenten Staphylococcus aureus (MRSA) erwiesen. Die Belastung durch Infektionskrankheiten nimmt weltweit zu, was dazu führt, dass der Fokus immer stärker auf deren Diagnose und Behandlung liegt
Ceftobiprol verfügt über antipseudomonale Eigenschaften, die weniger anfällig für die Entwicklung von Resistenzen zu sein scheinen. Ceftarolin wurde auch als Cephalosporin der fünften Generation beschrieben, verfügt jedoch nicht über die antipseudomonale oder VRE-Abdeckung von Ceftobiprol. Laut der Studie mit dem Titel Characterization and Clonal Diffusion of Ceftarolin Non-Susceptible MRSA in two Hospitals in Central Italy, die im August 2021 in MDPI Antibiotics veröffentlicht wurde, ist Ceftarolin, ein neuartiges Cephalosporin mit einer geringen Resistenzprävalenz, sehr wirksam gegen MRSA. Mutationen des Penicillin-bindenden Proteins (PBP) und Krankenhausklone von MRSA wie CC5, CC8 oder CC22 gehörten zu den Resistenzmechanismen. Die Tatsache, dass Cephalosporine der fünften Generation gegen im Krankenhaus übertragene MRSA-Infektionen wirksam sind und dass die Zahl der Infektionskrankheiten sowie längere Krankenhausaufenthalte stark ansteigen, unterstützt die Expansion des Marktes
Laut dem im Dezember 2020 veröffentlichten Artikel Die neuen Cephalosporine der fünften Generation – ein Gleichgewicht zwischen Sicherheit und Wirksamkeit sind Ceftarolinfosamile, die Kombination Ceftolozan/Tazobactam und Ceftobiprolmedocaril die ersten Vertreter der fünften Generation von Cephalosporinen, die in der Therapie eingesetzt werden. Diese neuen Antibiotika sind wertvolle Antiinfektiva mit einem positiven Verhältnis von Nutzen und Nebenwirkungen. Daher wird erwartet, dass das untersuchte Segment im Prognosezeitraum das Wachstum des Cephalosporin-Marktes vorantreiben wird
Der Markt wächst, da er die Türen für eine Alternative zur Behandlung komplizierter intraabdominaler Infektionen und komplizierter Harnwegsinfektionen geöffnet hat. Darüber hinaus wird Ceftolozan auch mit dem β-Lactamase-Hemmer Tazobactam kombiniert, da multiresistente bakterielle Infektionen grundsätzlich eine Resistenz gegen alle β-Lactam-Antibiotika aufweisen, sofern dieses Enzym nicht gehemmt wird. Daher könnte der zunehmende Einsatz von Kombinationstherapien den Markt im Prognosezeitraum antreiben
Aufgrund der oben genannten Faktoren wird daher erwartet, dass das Segmentwachstum im Prognosezeitraum vorangetrieben wird
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Nordamerika wird voraussichtlich das am stärksten wachsende Segment auf dem Weltmarkt sein
In Nordamerika wird aufgrund der steigenden Prävalenz von Infektionskrankheiten, der steigenden Gesundheitsausgaben und der großen Bevölkerungszahl ein hohes Wachstum erwartet. Darüber hinaus ist Cefuroxim ein Cephalosporin-Antibiotikum der zweiten Generation, das ein breites Wirkungsspektrum aufweist und häufig zur Behandlung von Infektionen der oberen und unteren Atemwege, der Lyme-Borreliose und Infektionen des Urogenitaltrakts eingesetzt wird. Es ist leicht verfügbar und erschwinglich und existiert sowohl in oraler als auch in parenteraler Form. Nach Angaben des Center for Disease Control and Prevention (CDC) wurden im Jahr 2020 in den Vereinigten Staaten etwa 7.174 neue Tuberkulosefälle festgestellt, was einer deutlich hohen Rate von 2,2 pro 100.000 Personen entspricht. Daher wird erwartet, dass die wachsende Belastung durch Infektionskrankheiten das Marktwachstum ankurbeln wird
Es wird erwartet, dass der Markt für Cephalosporin-Medikamente im geplanten Zeitraum aufgrund einer Aufstockung der Mittel für Forschung und Entwicklung (FE) von Cephalosporin-Arzneimitteln und Antibiotika wachsen wird. Beispielsweise erhielt CARB-X im Mai 2022 über einen Zeitraum von zehn Jahren bis zu 300 Millionen US-Dollar von der Biomedical Advanced Research and Development Authority (BARDA), einer Abteilung des US-amerikanischen Gesundheitsministeriums. Bis zu 70 Millionen US-Dollar werden über einen Zeitraum von drei Jahren von Wellcome bereitgestellt, einer globalen Wohltätigkeitsorganisation, die biomedizinische Forschung zur Bekämpfung von Antibiotikaresistenzen fördert. Beide spendeten in den ersten sechs Jahren als ursprüngliche Unterstützer des Projekts 355 Millionen US-Dollar. Daher fördern solche Bemühungen verschiedener Organisationen zur Entwicklung von Antibiotika die Marktexpansion im Prognosezeitraum
Darüber hinaus wird erwartet, dass strategische Aktivitäten der Marktteilnehmer wie Produkteinführungen, Fusionen und Übernahmen den Markt erweitern. Beispielsweise erwarb Sandoz im Oktober 2021 das Cephalosporin-Antibiotika-Geschäft von GSK. Durch diese Übernahme hat das Unternehmen Rechte an drei etablierten Marken (Zinnat, Zinacef und Fortum) in mehr als 100 Märkten erworben und damit seine weltweit führende Position bei Antibiotika weiter gestärkt
Außerdem gibt es einen Anstieg des Verbrauchs von Cephalosporin, eine einfachere Verfügbarkeit, eine steigende Nachfrage nach rezeptfreien Arzneimitteln und eine Zunahme bakterieller Infektionen in der Region, was das Marktwachstum vorantreibt
Marktgrößen- und Marktanteilsanalyse für Cephalosporin-Medikamente – Wachstumstrends und Prognosen (2024 – 2029)
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